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TW-37是Bcl-2的小分子抑制剂，可抑制胰腺癌细胞的生长，并通过一种涉及Notch-1和Jagged-1失活的新途径介导的胰腺癌细胞凋亡。
靶点信息
| Mcl-1 (Cell-free assay) | Bcl-2 (Cell-free assay) | Bcl-xL (Cell-free assay) | ||
| 0.26 μM(Ki) | 0.29 μM(Ki) | 1.11 μM(Ki) |
Cell data
| Cell Lines | Assay Description | Activity (IC50 μM) | Source |
|---|---|---|---|
| NB5 | Inhibition of human NB5 cell growth | 0.423358475 | Sanger |
| GP5d | Inhibition of human GP5d cell growth | 0.781758038 | Sanger |
| ES5 | Inhibition of human ES5 cell growth | 0.884301687 | Sanger |
| SK-MEL-30 | Inhibition of human SK-MEL-30 cell growth | 0.037974553 | Sanger |
| SK-MEL-5 | Inhibition of human SK-MEL-5 cell growth | 0.0692453 | Sanger |
| LK-2 | Inhibition of human LK-2 cell growth | 1.503431256 | Sanger |
| OVCAR-4 | Inhibition of human OVCAR-4 cell growth | 0.609531286 | Sanger |
| Becker | Inhibition of human Becker cell growth | 0.242111479 | Sanger |
| SK-LU-1 | Inhibition of human SK-LU-1 cell growth | 0.711414527 | Sanger |
| KYSE-520 cell line | Inhibition of human KYSE-520 cell growth | 4.138564547 | Sanger |
| NCI-H226 | Inhibition of human NCI-H226 cell growth | 2.459588354 | Sanger |
| SBC-5 | Inhibition of human SBC-5 cell growth | 0.147115101 | Sanger |
| MLMA | Inhibition of human MLMA cell growth | 0.185103158 | Sanger |
| KYSE-510 | Inhibition of human KYSE-510 cell growth | 0.22233545 | Sanger |
| NCI-N87 | Inhibition of human NCI-N87 cell growth | 2.196040574 | Sanger |
| UO-31 | Inhibition of human U031 cell growth | 0.183870789 | Sanger |
| COLO-829 | Inhibition of human COLO-829 cell growth | 0.700551778 | Sanger |
| AM-38 | Inhibition of human AM-38 cell growth | 0.840886152 | Sanger |
| ABC-1 | Inhibition of human ABC-1 cell growth | 0.315500188 | Sanger |
| 23132-87 | Inhibition of human 23132-87 cell growth | 0.32420508 | Sanger |
| CAL-12T | Inhibition of human CAL-12T cell growth | 1.121476365 | Sanger |
| CAL-120 | Inhibition of human CAL-120 cell growth | 0.479194361 | Sanger |
| BB65-RCC | Inhibition of human BB65-RCC cell growth | 0.134543999 | Sanger |
| COLO-668 | Inhibition of human COLO-668 cell growth | 5.099783052 | Sanger |
| BT-20 | Inhibition of human BT-20 cell growth | 0.655908488 | Sanger |
| COLO-679 | Inhibition of human COLO-679 cell growth | 0.233615191 | Sanger |
| A172 | Inhibition of human A172 cell growth | 0.793833133 | Sanger |
| BHT-101 | Inhibition of human BHT-101 cell growth | 0.021828824 | Sanger |
| NCI-H2347 | Inhibition of human NCI-H2347 cell growth | 1.222880327 | Sanger |
| SW1710 | Inhibition of human SW1710 cell growth | 0.388261188 | Sanger |
| UACC-62 | Inhibition of human UACC-62 cell growth | 0.034354887 | Sanger |
| K5 | Inhibition of human K5 cell growth | 1.766107549 | Sanger |
| ES7 | Inhibition of human ES7 cell growth | 0.27033996 | Sanger |
| DOK | Inhibition of human DOK cell growth | 1.342150261 | Sanger |
| SW780 | Inhibition of human SW780 cell growth | 5.799582893 | Sanger |
| A388 | Inhibition of human A388 cell growth | 0.167275521 | Sanger |
| BT-474 | Inhibition of human BT-474 cell growth | 3.866961281 | Sanger |
| ES3 | Inhibition of human ES3 cell growth | 0.358533564 | Sanger |
| EPLC-272H | Inhibition of human EPLC-272H cell growth | 0.702975668 | Sanger |
| D-566MG | Inhibition of human D-566MG cell growth | 0.115749026 | Sanger |
| EFM-19 | Inhibition of human EFM-19 cell growth | 1.585998219 | Sanger |
| COLO-741 | Inhibition of human COLO-741 cell growth | 1.369230633 | Sanger |
| BXPC-3 | Inhibition of human BxPC-3 cell growth | 2.48062613 | Sanger |
| COLO-792 | Inhibition of human COLO-792 cell growth | 0.24749448 | Sanger |
| C2BBe1 | Inhibition of human C2BBe1 cell growth | 0.266244558 | Sanger |
| C32 | Inhibition of human C32 cell growth | 2.015948895 | Sanger |
| LB771-HNC | Inhibition of human LB771-HNC cell growth | 0.165941494 | Sanger |
| NY | Inhibition of human NY cell growth | 0.177619972 | Sanger |
| MDA-MB-361 | Inhibition of human MDA-MB-361 cell growth | 0.2263984 | Sanger |
| IA-LM | Inhibition of human IA-LM cell growth | 1.557806902 | Sanger |
| TE-9 | Inhibition of human TE-9 cell growth | 0.224850397 | Sanger |
| GB-1 | Inhibition of human GB-1 cell growth | 0.098687992 | Sanger |
| KNS-81-FD | Inhibition of human KNS-81-FD cell growth | 0.247513043 | Sanger |
| RMG-I | Inhibition of human RMG-I cell growth | 0.206617504 | Sanger |
| MPP-89 | Inhibition of human MPP-89 cell growth | 1.272168596 | Sanger |
| LB2518-MEL | Inhibition of human LB2518-MEL cell growth | 0.177508639 | Sanger |
| YAPC | Inhibition of human YAPC cell growth | 0.801222174 | Sanger |
| HuO-3N1 | Inhibition of human HuO-3N1 cell growth | 2.031517397 | Sanger |
| TE-11 | Inhibition of human TE-11 cell growth | 0.150809776 | Sanger |
| SF-268 | Inhibition of human SF268 cell growth | 0.27160187 | Sanger |
| Hs-578-T | Inhibition of human Hs-578-T cell growth | 0.023589938 | Sanger |
| EW-22 | Inhibition of human EW-22 cell growth | 0.280097086 | Sanger |
| LAN-6 | Inhibition of human LAN-6 cell growth | 0.159920574 | Sanger |
| HCC1806 | Inhibition of human HCC1806 cell growth | 1.433478489 | Sanger |
| HuCCT1 | Inhibition of human HuCCT1 cell growth | 0.348027075 | Sanger |
| KINGS-1 | Inhibition of human KINGS-1 cell growth | 2.747224145 | Sanger |
| NCI-H1395 | Inhibition of human NCI-H1395 cell growth | 0.61190025 | Sanger |
| NCI-H2342 | Inhibition of human NCI-H2342 cell growth | 0.26656531 | Sanger |
| SNU-423 | Inhibition of human SNU-423 cell growth | 0.325009457 | Sanger |
| SNU-449 | Inhibition of human SNU-449 cell growth | 0.372394687 | Sanger |
| SW1990 | Inhibition of human SW1990 cell growth | 1.66757254 | Sanger |
| NCI-H28 | Inhibition of human NCI-H28 cell growth | 0.446634363 | Sanger |
| WM-115 | Inhibition of human WM-115 cell growth | 1.205324711 | Sanger |
| SNU-C2B | Inhibition of human SNU-C2B cell growth | 0.257360617 | Sanger |
| HuO9 | Inhibition of human HuO9 cell growth | 0.727395451 | Sanger |
| HUTU-80 | Inhibition of human HUTU-80 cell growth | 0.087005582 | Sanger |
| LXF-289 cell line | Inhibition of human LXF-289 cell growth | 0.072846995 | Sanger |
| LoVo | Inhibition of human LoVo cell growth | 0.160931737 | Sanger |
| VMRC-RCZ | Inhibition of human VMRC-RCZ cell growth | 7.75108629 | Sanger |
| U-118-MG | Inhibition of human U-118-MG cell growth | 0.190033482 | Sanger |
| KYSE-180 | Inhibition of human KYSE-180 cell growth | 0.184878394 | Sanger |
| SW 954 | Inhibition of human SW954 cell growth | 0.46695518 | Sanger |
| EW-1 | Inhibition of human EW-1 cell growth | 0.226802202 | Sanger |
| NCI-H2122 | Inhibition of human NCI-H2122 cell growth | 0.537562633 | Sanger |
| MKN1 | Inhibition of human MKN1 cell growth | 0.623270291 | Sanger |
| SK-N-AS | Inhibition of human SK-N-AS cell growth | 0.181183128 | Sanger |
| S-117 | Inhibition of human S-117 cell growth | 0.213291394 | Sanger |
| NCI-H2087 | Inhibition of human NCI-H2087 cell growth | 0.575072592 | Sanger |
| OVCAR-3 | Inhibition of human OVCAR-3 cell growth | 0.379172133 | Sanger |
| MG-63 | Inhibition of human MG-63 cell growth | 0.112478409 | Sanger |
| OVCAR-5 | Inhibition of human OVCAR-5 cell growth | 0.575715307 | Sanger |
| LS-411N | Inhibition of human LS-411N cell growth | 1.244201551 | Sanger |
| FTC-133 | Inhibition of human FTC-133 cell growth | 0.606634992 | Sanger |
| LCLC-97TM1 | Inhibition of human LCLC-97TM1 cell growth | 0.917272212 | Sanger |
| KLE | Inhibition of human KLE cell growth | 1.944366078 | Sanger |
| NCI-H1648 | Inhibition of human NCI-H1648 cell growth | 1.122238106 | Sanger |
| NCI-H1651 | Inhibition of human NCI-H1651 cell growth | 1.001072575 | Sanger |
| PANC-08-13 | Inhibition of human PANC-08-13 cell growth | 3.765648158 | Sanger |
| LU-99A | Inhibition of human LU-99A cell growth | 0.273763961 | Sanger |
| NCI-H1299 | Inhibition of human NCI-H1299 cell growth | 0.280244456 | Sanger |
| MZ7-mel | Inhibition of human MZ7-mel cell growth | 1.732502682 | Sanger |
| GAMG | Inhibition of human GAMG cell growth | 0.212382794 | Sanger |
| SW1088 | Inhibition of human SW1088 cell growth | 0.454598803 | Sanger |
| SJRH30 | Inhibition of human SJRH30 cell growth | 0.136519612 | Sanger |
| TE-5 | Inhibition of human TE-5 cell growth | 0.884431689 | Sanger |
| no-11 | Inhibition of human no-11 cell growth | 2.836185456 | Sanger |
| RPMI-2650 | Inhibition of human RPMI-2650 cell growth | 0.238308792 | Sanger |
| TGBC1TKB | Inhibition of human TGBC1TKB cell growth | 1.127328867 | Sanger |
| LB996-RCC | Inhibition of human LB996-RCC cell growth | 0.250013841 | Sanger |
| SiHa | Inhibition of human SiHa cell growth | 0.26109316 | Sanger |
| IGR-1 | Inhibition of human IGR-1 cell growth | 0.300611664 | Sanger |
| SW1463 | Inhibition of human SW1463 cell growth | 64.83567552 | Sanger |
| MeWo | Inhibition of human Mewo cell growth | 0.484129425 | Sanger |
| UACC-893 | Inhibition of human UACC-893 cell growth | 1.434916989 | Sanger |
| UMUC3 | Inhibition of human UM-UC-3 cell growth | 0.163114805 | Sanger |
| MES-SA | Inhibition of human MES-SA cell growth | 1.109971123 | Sanger |
| EW-11 | Inhibition of human EW-11 cell growth | 0.434168748 | Sanger |
| DU-145 | Inhibition of human DU-145 cell growth | 0.052128211 | Sanger |
| EFO-21 | Inhibition of human EFO-21 cell growth | 2.602443991 | Sanger |
| CAL-51 | Inhibition of human CAL-51 cell growth | 0.349116361 | Sanger |
| ACN | Inhibition of human ACN cell growth | 0.696006695 | Sanger |
| CAMA-1 | Inhibition of human CAMA-1 cell growth | 0.660731318 | Sanger |
| BB49-HNC | Inhibition of human BB49-HNC cell growth | 2.014721556 | Sanger |
| A673 | Inhibition of human A673 cell growth | 0.053845201 | Sanger |
| A498 | Inhibition of human A498 cell growth | 1.494733605 | Sanger |
| ES1 | Inhibition of human ES1 cell growth | 0.12955536 | Sanger |
| CP50-MEL-B | Inhibition of human CP50-MEL-B cell growth | 0.069594691 | Sanger |
| COR-L105 | Inhibition of human COR-L105 cell growth | 0.710648035 | Sanger |
| D-542MG | Inhibition of human D-542MG cell growth | 0.462080112 | Sanger |
| D-423MG | Inhibition of human D-423MG cell growth | 0.472803694 | Sanger |
| CAS-1 | Inhibition of human CAS-1 cell growth | 2.779510964 | Sanger |
| SW626 | Inhibition of human SW626 cell growth | 0.422985238 | Sanger |
| NB12 | Inhibition of human NB12 cell growth | 0.136450823 | Sanger |
| NCI-H596 | Inhibition of human NCI-H596 cell growth | 3.322847181 | Sanger |
| EGI-1 | Inhibition of human EGI-1 cell growth | 1.246855772 | Sanger |
| PC3 | Inhibition of growth of human PC3 cell overexpressing Bcl2 | 0.2 | Scientific Literature |
| FaDu | Inhibition of human FADU cell growth | 0.525761811 | Sanger |
| NTERA-2-cl-D1 | Inhibition of human NTERA-S-cl-D1 cell growth | 0.166677579 | Sanger |
| HCE-T | Inhibition of human HCE-T cell growth | 0.230974723 | Sanger |
| MDA-MB-231 | Inhibition of human MDA-MB-231 cell growth | 0.108073579 | Sanger |
| HuP-T4 | Inhibition of human HuP-T4 cell growth | 0.542751341 | Sanger |
| GT3TKB | Inhibition of human GT3TKB cell growth | 0.300583408 | Sanger |
| RVH-421 | Inhibition of human RVH-421 cell growth | 0.252611132 | Sanger |
| HOP-92 | Inhibition of human HOP-92 cell growth | 0.357614389 | Sanger |
| SW872 | Inhibition of human SW872 cell growth | 0.058897714 | Sanger |
| SW900 | Inhibition of human SW900 cell growth | 2.769860617 | Sanger |
| Daoy | Inhibition of human Daoy cell growth | 0.140732268 | Sanger |
| DSH1 | Inhibition of human DSH1 cell growth | 0.516608471 | Sanger |
| ES4 | Inhibition of human ES4 cell growth | 0.516076639 | Sanger |
| SW1783 | Inhibition of human SW1783 cell growth | 0.213006201 | Sanger |
| TYK-nu | Inhibition of human TYK-nu cell growth | 0.324473633 | Sanger |
| NCI-H2029 | Inhibition of human NCI-H2029 cell growth | 14.37849949 | Sanger |
| NCI-H650 | Inhibition of human NCI-H650 cell growth | 0.645765399 | Sanger |
| OVCAR-8 | Inhibition of human OVCAR-8 cell growth | 0.470990667 | Sanger |
| NB69 | Inhibition of human NB69 cell growth | 0.876724917 | Sanger |
| HPAF-II | Inhibition of human HPAF-II cell growth | 0.228111896 | Sanger |
| SK-OV-3 | Inhibition of human SK-OV-3 cell growth | 0.527129516 | Sanger |
| U-251 | Inhibition of human U251 cell growth | 0.38838118 | Sanger |
| RPMI-7951 | Inhibition of human RPMI-7951 cell growth | 0.888310442 | Sanger |
| SW620 | Inhibition of human SW620 cell growth | 0.960571365 | Sanger |
| GI-1 | Inhibition of human GI-1 cell growth | 0.127632403 | Sanger |
| SCC-25 | Inhibition of human SCC-25 cell growth | 0.522661109 | Sanger |
| SK-UT-1 | Inhibition of human SK-UT-1 cell growth | 0.028682302 | Sanger |
| UMC-11 | Inhibition of human UMC-11 cell growth | 1.313887106 | Sanger |
| VA-ES-BJ | Inhibition of human VA-ES-BJ cell growth | 0.039563789 | Sanger |
| GCT | Inhibition of human GCT cell growth | 0.191134865 | Sanger |
| NCI-H358 | Inhibition of human NCI-H358 cell growth | 1.492621545 | Sanger |
| NUGC-3 | Inhibition of human NUGC-3 cell growth | 1.147931928 | Sanger |
| SW13 | Inhibition of human SW13 cell growth | 0.20359043 | Sanger |
| NCI-H1666 | Inhibition of human NCI-H1666 cell growth | 0.37831882 | Sanger |
| HEC-1 | Inhibition of human HEC-1 cell growth | 0.081370295 | Sanger |
| ACHN | Inhibition of human ACHN cell growth | 0.149001188 | Sanger |
| BB30-HNC | Inhibition of human BB30-HNC cell growth | 0.161744556 | Sanger |
| DMS-114 | Inhibition of human DMS-114 cell growth | 0.090707703 | Sanger |
| 5637 | Inhibition of human 5637 cell growth | 0.551672889 | Sanger |
| DMS-53 | Inhibition of human DMS-53 cell growth | 1.321314402 | Sanger |
| D283 Med | Inhibition of human D-283MED cell growth | 0.284374002 | Sanger |
| D-336MG | Inhibition of human D-336MG cell growth | 0.957613526 | Sanger |
| Huh-7 | Inhibition of human HuH-7 cell growth | 0.032824011 | Sanger |
| YKG-1 | Inhibition of human YKG-1 cell growth | 0.029757621 | Sanger |
| COLO-824 | Inhibition of human COLO-824 cell growth | 0.691187601 | Sanger |
| NCI-H1838 | Inhibition of human NCI-H1838 cell growth | 2.156464338 | Sanger |
| MFM-223 | Inhibition of human MFM-223 cell growth | 0.846921728 | Sanger |
| NB14 | Inhibition of human NB14 cell growth | 0.076449797 | Sanger |
| BCPAP | Inhibition of human BCPAP cell growth | 0.24164393 | Sanger |
| NCI-H1703 | Inhibition of human NCI-H1703 cell growth | 0.217092011 | Sanger |
| SW1573 | Inhibition of human SW1573 cell growth | 0.240164302 | Sanger |
| MFE-280 | Inhibition of human MFE-280 cell growth | 4.587833921 | Sanger |
| IST-MEL1 | Inhibition of human IST-MEL1 cell growth | 0.227889139 | Sanger |
| NCI-H1792 | Inhibition of human NCI-H1792 cell growth | 0.690072234 | Sanger |
| MDA-MB-157 | Inhibition of human MDA-MB-157 cell growth | 0.841367277 | Sanger |
| MSTO-211H | Inhibition of human MSTO-211H cell growth | 0.788541691 | Sanger |
| PA-1 | Inhibition of human PA-1 cell growth | 0.133663878 | Sanger |
| MMAC-SF | Inhibition of human MMAC-SF cell growth | 3.143890356 | Sanger |
| HCC1419 | Inhibition of human HCC1419 cell growth | 0.918189025 | Sanger |
| NCI-H1355 | Inhibition of human NCI-H1355 cell growth | 1.29157577 | Sanger |
| HT-1376 | Inhibition of human HT-1376 cell growth | 1.902045717 | Sanger |
| HT-144 | Inhibition of human HT-144 cell growth | 0.152010452 | Sanger |
| KYSE-450 | Inhibition of human KYSE-450 cell growth | 0.175337779 | Sanger |
| HCC1187 | Inhibition of human HCC1187 cell growth | 0.424970723 | Sanger |
| NCI-H630 | Inhibition of human NCI-H630 cell growth | 0.807670581 | Sanger |
| NB10 | Inhibition of human NB10 cell growth | 0.214685309 | Sanger |
| NCI-H460 | Inhibition of human NCI-H460 cell growth | 0.305736702 | Sanger |
| OAW-28 | Inhibition of human OAW-28 cell growth | 0.293841727 | Sanger |
| KOSC-2 | Inhibition of human KOSC-2 cell growth | 0.495735381 | Sanger |
| KP-N-YN | Inhibition of human KP-N-YN cell growth | 15.93034849 | Sanger |
| Ca9-22 | Inhibition of human Ca9-22 cell growth | 0.00382021 | Sanger |
| 769-P | Inhibition of human 769-P cell growth | 0.136837526 | Sanger |
| 8305C | Inhibition of human 8305C cell growth | 3.910076738 | Sanger |
| D-247MG | Inhibition of human D-247MG cell growth | 0.935745258 | Sanger |
| CHP-212 | Inhibition of human CHP-212 cell growth | 4.572371509 | Sanger |
| COLO-678 | Inhibition of human COLO-678 cell growth | 3.306879515 | Sanger |
| J82 | Inhibition of human J82 cell growth | 1.128415008 | Sanger |
| SK-MG-1 | Inhibition of human SK-MG-1 cell growth | 2.582939264 | Sanger |
| ES6 | Inhibition of human ES6 cell growth | 0.373344385 | Sanger |
| CAL-27 | Inhibition of human CAL-27 cell growth | 0.135786294 | Sanger |
| ChaGo-K-1 | Inhibition of human ChaGo-K-1 cell growth | 0.295667727 | Sanger |
| A101D | Inhibition of human A101D cell growth | 0.087504155 | Sanger |
| SH-4 | Inhibition of human SH-4 cell growth | 0.226829873 | Sanger |
| MZ2-MEL | Inhibition of human MZ2-MEL cell growth | 0.212442482 | Sanger |
| NCI-H1650 | Inhibition of human NCI-H1650 cell growth | 4.924919848 | Sanger |
| G-401 | Inhibition of human G-401 cell growth | 0.459929988 | Sanger |
| MC-IXC | Inhibition of human MC-IXC cell growth | 0.075330664 | Sanger |
| EW-16 | Inhibition of human EW-16 cell growth | 0.185278348 | Sanger |
| TCC-SUP | Inhibition of human TCCSUP cell growth | 0.36069556 | Sanger |
| SKG-IIIa | Inhibition of human SKG-IIIa cell growth | 0.576071209 | Sanger |
| HCC1954 | Inhibition of human HCC1954 cell growth | 0.893956645 | Sanger |
| SJSA-1 | Inhibition of human SJSA-1 cell growth | 0.326681692 | Sanger |
| SW1417 | Inhibition of human SW1417 cell growth | 1.908720267 | Sanger |
| NCI-H1755 | Inhibition of human NCI-H1755 cell growth | 1.621168199 | Sanger |
| HEL | Inhibition of human HEL cell growth | 0.521663257 | Sanger |
| SW962 | Inhibition of human SW962 cell growth | 0.377909322 | Sanger |
| SW982 | Inhibition of human SW982 cell growth | 0.110697945 | Sanger |
| SCC-15 | Inhibition of human SCC-15 cell growth | 0.222852982 | Sanger |
| PC-3 | Inhibition of human PC-3 cell growth | 0.71542107 | Sanger |
| NCI-H2170 | Inhibition of human NCI-H2170 cell growth | 1.001693432 | Sanger |
| HCC1395 | Inhibition of human HCC1395 cell growth | 7.113127354 | Sanger |
| HCC1569 | Inhibition of human HCC1569 cell growth | 4.876881604 | Sanger |
| HT-1197 | Inhibition of human HT-1197 cell growth | 5.950879359 | Sanger |
| HSC-4 | Inhibition of human HSC-4 cell growth | 0.21323296 | Sanger |
| KALS-1 | Inhibition of human KALS-1 cell growth | 0.252548745 | Sanger |
| KYSE-70 cell line | Inhibition of human KYSE-70 cell growth | 5.30761722 | Sanger |
| KGN | Inhibition of human KGN cell growth | 0.436233338 | Sanger |
| HCE-4 | Inhibition of human HCE-4 cell growth | 0.469060744 | Sanger |
| NCI-H1581 | Inhibition of human NCI-H1581 cell growth | 0.067635046 | Sanger |
| TE-1 | Inhibition of human TE-1 cell growth | 0.957478512 | Sanger |
| SF295 | Inhibition of human SF295 cell growth | 0.628932086 | Sanger |
| HCC38 | Inhibition of human HCC38 cell growth | 0.676390302 | Sanger |
| CAL-72 | Inhibition of human CAL-72 cell growth | 0.967539527 | Sanger |
| CAL-85-1 | Inhibition of human CAL-85-1 cell growth | 1.432697456 | Sanger |
| Calu-3 | Inhibition of human Calu-3 cell growth | 5.397398078 | Sanger |
| 786-0 | Inhibition of human 786-0 cell growth | 6.974042205 | Sanger |
| BFTC-905 | Inhibition of human BFTC-905 cell growth | 0.70817857 | Sanger |
| BFTC-909 | Inhibition of human BFTC-909 cell growth | 0.25791299 | Sanger |
| CAKI-1 | Inhibition of human CAKI-1 cell growth | 0.216437815 | Sanger |
| COLO-800 | Inhibition of human COLO-800 cell growth | 0.183089715 | Sanger |
| EKVX | Inhibition of human EKVX cell growth | 7.141236924 | Sanger |
| Detroit 562 | Inhibition of human Detroit562 cell growth | 1.274468208 | Sanger |
| IST-MES1 | Inhibition of human IST-MES1 cell growth | 0.213733365 | Sanger |
| OMC-1 | Inhibition of human OMC-1 cell growth | 0.565464365 | Sanger |
| RT-112 | Inhibition of human RT-112 cell growth | 0.534544124 | Sanger |
| SK-MEL-28 | Inhibition of human SK-MEL-28 cell growth | 1.389836341 | Sanger |
| SW684 | Inhibition of human SW684 cell growth | 8.825788965 | Sanger |
| NCI-H2009 | Inhibition of human NCI-H2009 cell growth | 0.244659703 | Sanger |
| NCI-H727 | Inhibition of human NCI-H727 cell growth | 0.940971902 | Sanger |
| NB7 | Inhibition of human NB7 cell growth | 0.029278729 | Sanger |
| ES8 | Inhibition of human ES8 cell growth | 0.11926731 | Sanger |
| H-EMC-SS | Inhibition of human H-EMC-SS cell growth | 0.378225008 | Sanger |
| NCI-H1975 | Inhibition of human NCI-H1975 cell growth | 1.375864141 | Sanger |
| SAS | Inhibition of human SAS cell growth | 0.033182953 | Sanger |
| No Data | Displacement of FAM-Bak from human Bcl-xL by FP assay | 6.58 | Scientific Literature |
| CaR-1 | Inhibition of human CaR-1 cell growth | 5.931072164 | Sanger |
| A204 | Inhibition of human A204 cell growth | 0.097844089 | Sanger |
| Calu-6 | Inhibition of human Calu-6 cell growth | 0.886751938 | Sanger |
| 8-MG-BA | Inhibition of human 8-MG-BA cell growth | 0.15395776 | Sanger |
| AU565 | Inhibition of human AU565 cell growth | 0.352654308 | Sanger |
| SNU-387 | Inhibition of human SNU-387 cell growth | 0.247832541 | Sanger |
| PFSK-1 | Inhibition of human PFSK-1 cell growth | 0.17672808 | Sanger |
| PSN1 | Inhibition of human PSN1 cell growth | 0.167242236 | Sanger |
| NCI-H1563 | Inhibition of human NCI-H1563 cell growth | 0.124204857 | Sanger |
| TE-10 | Inhibition of human TE-10 cell growth | 1.234161757 | Sanger |
| Panc1005 | Inhibition of human PANC-10-05 cell growth | 1.102974918 | Sanger |
| RCC10RGB | Inhibition of human RCC10RGB cell growth | 13.83731599 | Sanger |
| LN-405 | Inhibition of human LN-405 cell growth | 1.583771456 | Sanger |
| SK-MEL-2 | Inhibition of human SK-MEL-2 cell growth | 0.230186138 | Sanger |
| NCI-H1623 | Inhibition of human NCI-H1623 cell growth | 0.59527964 | Sanger |
| EC-GI-10 | Inhibition of human EC-GI-10 cell growth | 0.469820769 | Sanger |
| DJM-1 | Inhibition of human DJM-1 cell growth | 0.519965404 | Sanger |
| DMS-273 | Inhibition of human DMS-273 cell growth | 0.100200109 | Sanger |
| CAL-39 | Inhibition of human CAL-39 cell growth | 0.341067798 | Sanger |
| C3A | Inhibition of human C3A cell growth | 1.820612531 | Sanger |
| A549 | Inhibition of human A549 cell growth | 0.014089929 | Sanger |
| C-33-A | Inhibition of human C-33-A cell growth | 0.109332236 | Sanger |
| M14 | Inhibition of human M14 cell growth | 2.827534131 | Sanger |
| NCI-H23 | Inhibition of human NCI-H23 cell growth | 0.34786041 | Sanger |
| SCH | Inhibition of human SCH cell growth | 0.367480141 | Sanger |
| EVSA-T | Inhibition of human EVSA-T cell growth | 0.139934055 | Sanger |
| HCC70 | Inhibition of human HCC70 cell growth | 0.857868032 | Sanger |
| KP-4 | Inhibition of human KP-4 cell growth | 0.454968542 | Sanger |
| OCUB-M | Inhibition of human OCUB-M cell growth | 0.242769462 | Sanger |
| LC-2-ad | Inhibition of human LC-2-ad cell growth | 0.424154713 | Sanger |
| MEL-HO | Inhibition of human MEL-HO cell growth | 0.088161317 | Sanger |
| HGC-27 | Inhibition of human HGC-27 cell growth | 0.14048255 | Sanger |
| RERF-LC-MS | Inhibition of human RERF-LC-MS cell growth | 0.035186141 | Sanger |
| HCC2998 | Inhibition of human HCC2998 cell growth | 5.891437349 | Sanger |
| KNS-62 | Inhibition of human KNS-62 cell growth | 0.559451746 | Sanger |
| GAK | Inhibition of human GAK cell growth | 2.027884233 | Sanger |
| RH-18 | Inhibition of human RH-18 cell growth | 1.07462418 | Sanger |
| TE-8 | Inhibition of human TE-8 cell growth | 0.129261732 | Sanger |
| NCI-H441 | Inhibition of human NCI-H441 cell growth | 1.729198489 | Sanger |
| IGROV-1 | Inhibition of human IGROV-1 cell growth | 0.453621559 | Sanger |
| T-24 | Inhibition of human T-24 cell growth | 0.294556336 | Sanger |
| SCC-9 | Inhibition of human SCC-9 cell growth | 0.957159725 | Sanger |
| HT-29 | Inhibition of human HT-29 cell growth | 1.464374223 | Sanger |
| T98G | Inhibition of human T98G cell growth | 0.606121996 | Sanger |
| RXF393 | Inhibition of human RXF393 cell growth | 1.211592973 | Sanger |
| SW837 | Inhibition of human SW837 cell growth | 2.390259649 | Sanger |
| U-2-OS | Inhibition of human U-2-OS cell growth | 0.551816343 | Sanger |
| NCI-H747 | Inhibition of human NCI-H747 cell growth | 0.129633376 | Sanger |
| KYSE-410 | Inhibition of human KYSE-410 cell growth | 0.877179178 | Sanger |
| LS-513 | Inhibition of human LS-513 cell growth | 0.606504579 | Sanger |
| ESS-1 | Inhibition of human ESS-1 cell growth | 0.140874621 | Sanger |
| MKN28 | Inhibition of human MKN28 cell growth | 1.132093983 | Sanger |
| KS-1 | Inhibition of human KS-1 cell growth | 0.321781672 | Sanger |
| LB373-MEL-D | Inhibition of human LB373-MEL-D cell growth | 0.430920354 | Sanger |
| LB2241-RCC | Inhibition of human LB2241-RCC cell growth | 0.146583214 | Sanger |
| HOP-62 | Inhibition of human HOP-62 cell growth | 0.365388539 | Sanger |
| 639-V | Inhibition of human 639-V cell growth | 0.521382157 | Sanger |
| A253 | Inhibition of human A253 cell growth | 0.570186374 | Sanger |
| D-392MG | Inhibition of human D-392MG cell growth | 1.419831212 | Sanger |
| OE19 | Inhibition of human OE19 cell growth | 5.977545308 | Sanger |
| A-375 | Inhibition of human A375 cell growth | 0.088830075 | Sanger |
| HMV-2 cell line | Inhibition of human HMV-II cell growth | 0.309307299 | Sanger |
| SK-MEL-3 | Inhibition of human SK-MEL-3 cell growth | 0.692574822 | Sanger |
| MHH-ES-1 | Inhibition of human MHH-ES-1 cell growth | 0.50038724 | Sanger |
| KYSE-140 | Inhibition of human KYSE-140 cell growth | 0.186431761 | Sanger |
| NCI-H1993 | Inhibition of human NCI-H1993 cell growth | 1.040036699 | Sanger |
| OS-RC-2 | Inhibition of human OS-RC-2 cell growth | 0.737249433 | Sanger |
| DBTRG-05MG | Inhibition of human DBTRG-05MG cell growth | 1.457808091 | Sanger |
| BHY | Inhibition of human BHY cell growth | 0.701651807 | Sanger |
| OE33 | Inhibition of human OE33 cell growth | 0.695431335 | Sanger |
| TGBC24TKB | Inhibition of human TGBC24TKB cell growth | 0.226539717 | Sanger |
| JAR | Inhibition of human JAR cell growth | 0.002601646 | Sanger |
| TK-10 | Inhibition of human TK10 cell growth | 0.462023742 | Sanger |
| GMS-10 | Inhibition of human GMS-10 cell growth | 0.44325857 | Sanger |
| NCI-H2030 | Inhibition of human NCI-H2030 cell growth | 2.805531489 | Sanger |
| KU-19-19 | Inhibition of human KU-19-19 cell growth | 0.440307911 | Sanger |
| HN | Inhibition of human HN cell growth | 0.231342496 | Sanger |
| NCI-H2052 | Inhibition of human NCI-H2052 cell growth | 1.392934956 | Sanger |
| SW756 | Inhibition of human SW756 cell growth | 0.112363177 | Sanger |
| G-361 | Inhibition of human G-361 cell growth | 0.124951077 | Sanger |
| NCI-H2452 | Inhibition of human NCI-H2452 cell growth | 0.754248794 | Sanger |
| SF539 | Inhibition of human SF539 cell growth | 0.470139885 | Sanger |
| HCT-116 | Inhibition of human HCT-116 cell growth | 0.052657848 | Sanger |
| ZR-75-30 | Inhibition of human ZR-75-30 cell growth | 1.422077741 | Sanger |
| no-10 | Inhibition of human no-10 cell growth | 0.276994397 | Sanger |
| RH-1 | Inhibition of human RH-1 cell growth | 0.157724254 | Sanger |
| MZ1-PC | Inhibition of human MZ1-PC cell growth | 0.634910649 | Sanger |
| SHP-77 | Inhibition of human SHP-77 cell growth | 0.451411021 | Sanger |
| SIMA | Inhibition of human SIMA cell growth | 0.664317554 | Sanger |
| KNS-42 | Inhibition of human KNS-42 cell growth | 2.544275669 | Sanger |
| DK-MG | Inhibition of human DK-MG cell growth | 2.902205601 | Sanger |
| Aspc-1 | Inhibition of human AsPC-1 cell growth | 0.973461503 | Sanger |
| CP66-MEL | Inhibition of human CP66-MEL cell growth | 1.203294245 | Sanger |
| CAL-54 | Inhibition of human CAL-54 cell growth | 0.160738895 | Sanger |
| LOXIMVI | Inhibition of human LOXIMVI cell growth | 0.270707331 | Sanger |
| HOS | Inhibition of human HOS cell growth | 0.084705478 | Sanger |
| JEG-3 | Inhibition of human JEG-3 cell growth | 0.735697684 | Sanger |
| SK-MES-1 | Inhibition of human SK-MES-1 cell growth | 1.044939511 | Sanger |
| MIA PaCa-2 | Inhibition of human MIA-PaCa-2 cell growth | 0.479111467 | Sanger |
| SK-N-FI | Inhibition of human SK-N-FI cell growth | 0.327753984 | Sanger |
| U-87 MG | Inhibition of human U-87-MG cell growth | 0.082236585 | Sanger |
| HSC-3 | Inhibition of human HSC-3 cell growth | 0.286447788 | Sanger |
| NCI-H2228 | Inhibition of human NCI-H2228 cell growth | 0.661730438 | Sanger |
| LB1047-RCC | Inhibition of human LB1047-RCC cell growth | 0.319335821 | Sanger |
| NEC8 | Inhibition of human NEC8 cell growth | 0.145282377 | Sanger |
| HTC-C3 | Inhibition of human HTC-C3 cell growth | 1.584197548 | Sanger |
| NCI-H1437 | Inhibition of human NCI-H1437 cell growth | 0.538336742 | Sanger |
| NCI-H2405 | Inhibition of human NCI-H2405 cell growth | 0.674567186 | Sanger |
| RCM-1 | Inhibition of human RCM-1 cell growth | 3.389410458 | Sanger |
| MCF7 | Inhibition of human MCF7 cell growth | 0.336900717 | Sanger |
| 8505C | Inhibition of human 8505C cell growth | 0.221287615 | Sanger |
| BPH-1 | Inhibition of human BPH-1 cell growth | 0.285812008 | Sanger |
| COLO-680N | Inhibition of human COLO-680N cell growth | 1.434750548 | Sanger |
| D-263MG | Inhibition of human D-263MG cell growth | 0.283492957 | Sanger |
| A-431 | Inhibition of human A431 cell growth | 1.469122083 | Sanger |
| BT-549 | Inhibition of human BT-549 cell growth | 0.679860261 | Sanger |
| A2058 | Inhibition of human A2058 cell growth | 0.366906952 | Sanger |
| D-502MG | Inhibition of human D-502MG cell growth | 4.922019924 | Sanger |
| ONS-76 | Inhibition of human ONS-76 cell growth | 0.325261762 | Sanger |
| ETK-1 | Inhibition of human ETK-1 cell growth | 0.788280727 | Sanger |
| SN12C | Inhibition of human SN12C cell growth | 1.106997062 | Sanger |
| T47D | Inhibition of human T47D cell growth | 0.690672858 | Sanger |
| HT-1080 | Inhibition of human HT-1080 cell growth | 0.255526029 | Sanger |
| OAW-42 | Inhibition of human OAW-42 cell growth | 0.491976169 | Sanger |
| OC-314 | Inhibition of human OC-314 cell growth | 0.210151202 | Sanger |
| EFO-27 | Inhibition of human EFO-27 cell growth | 0.117212588 | Sanger |
| 647-V | Inhibition of human 647-V cell growth | 0.088427966 | Sanger |
| RO82-W-1 | Inhibition of human RO82-W-1 cell growth | 0.39777212 | Sanger |
| SK-LMS-1 | Inhibition of human SK-LMS-1 cell growth | 0.271512527 | Sanger |
| NCI-H522 | Inhibition of human NCI-H522 cell growth | 2.084568751 | Sanger |
| SK-HEP-1 | Inhibition of human SK-HEP-1 cell growth | 1.513696996 | Sanger |
| NCI-H520 | Inhibition of human NCI-H520 cell growth | 0.605663335 | Sanger |
| MEL-JUSO | Inhibition of human MEL-JUSO cell growth | 0.438583966 | Sanger |
| GCIY | Inhibition of human GCIY cell growth | 0.020826626 | Sanger |
| No Data | Binding affinity to human Bcl2 by ELISA | 0.7 | Scientific Literature |
| No Data | Displacement of FAM-Bid from human Mcl1 by FP assay | 1.03 | Scientific Literature |
| IST-SL1 | Inhibition of human IST-SL1 cell growth | 0.438362976 | Sanger |
| NB6 | Inhibition of human NB6 cell growth | 2.485895607 | Sanger |
| GI-ME-N | Inhibition of human GI-ME-N cell growth | 0.403175632 | Sanger |
| NB13 | Inhibition of human NB13 cell growth | 0.158009203 | Sanger |
| NCI-H661 | Inhibition of human NCI-H661 cell growth | 0.201668302 | Sanger |
| LS-123 | Inhibition of human LS-123 cell growth | 2.195021848 | Sanger |
| NB17 | Inhibition of human NB17 cell growth | 1.064232625 | Sanger |
| KYSE-150 cell line | Inhibition of human KYSE-150 cell growth | 0.465109694 | Sanger |
| RT4 | Inhibition of human RT4 cell growth | 10.61829015 | Sanger |
| SK-N-DZ | Inhibition of human SK-N-DZ cell growth | 0.206814505 | Sanger |
| SW948 | Inhibition of human SW948 cell growth | 32.72407351 | Sanger |
| NCI-H1048 | Inhibition of human NCI-H1048 cell growth | 0.214268581 | Sanger |
| HSC-2 | Inhibition of human HSC-2 cell growth | 0.663804899 | Sanger |
| NCI-H810 | Inhibition of human NCI-H810 cell growth | 0.666041032 | Sanger |
| SF126 | Inhibition of human SF126 cell growth | 0.057072151 | Sanger |
| AN3-CA | Inhibition of human AN3-CA cell growth | 0.897582716 | Sanger |
| LNCaP-Clone-FGC | Inhibition of human LNCaP-Clone-FGC cell growth | 0.534717344 | Sanger |
| SK-MEL-24 | Inhibition of human SK-MEL-24 cell growth | 0.409914778 | Sanger |
| T84 | Inhibition of human T84 cell growth | 13.87372828 | Sanger |
| SCC-4 | Inhibition of human SCC-4 cell growth | 1.302361298 | Sanger |
| CAPAN-1 | Inhibition of human CAPAN-1 cell growth | 10.84385977 | Sanger |
| MKN7 | Inhibition of human MKN7 cell growth | 4.469010413 | Sanger |
| PANC-03-27 | Inhibition of human PANC-03-27 cell growth | 0.474135089 | Sanger |
| NCI-H2126 | Inhibition of human NCI-H2126 cell growth | 0.782367265 | Sanger |
| HO-1-N-1 | Inhibition of human HO-1-N-1 cell growth | 1.418559613 | Sanger |
| GOTO | Inhibition of human GOTO cell growth | 0.170946609 | Sanger |
| NCI-H1793 | Inhibition of human NCI-H1793 cell growth | 0.745254879 | Sanger |
| A2780 | Inhibition of human A2780 cell growth | 0.218457236 | Sanger |
| A-427 | Inhibition of human A427 cell growth | 0.044693196 | Sanger |
| KYSE-270 | Inhibition of human KYSE-270 cell growth | 1.075766037 | Sanger |
| UACC-257 | Inhibition of human UACC-257 cell growth | 0.551786546 | Sanger |
| HLE | Inhibition of human HLE cell growth | 0.120990772 | Sanger |
| KURAMOCHI | Inhibition of human KURAMOCHI cell growth | 1.935154174 | Sanger |
| SW48 | Inhibition of human SW48 cell growth | 0.237988958 | Sanger |
| LS-1034 | Inhibition of human LS-1034 cell growth | 1.36440304 | Sanger |
| SW1116 | Inhibition of human SW1116 cell growth | 8.447900931 | Sanger |
| H4 | Inhibition of human H4 cell growth | 0.408124094 | Sanger |
| MKN45 | Inhibition of human MKN45 cell growth | 0.337751453 | Sanger |
| TE-6 | Inhibition of human TE-6 cell growth | 24.50078113 | Sanger |
| G-402 | Inhibition of human G-402 cell growth | 0.192980139 | Sanger |
| LB831-BLC | Inhibition of human LB831-BLC cell growth | 0.744784771 | Sanger |
| HCT-15 | Inhibition of human HCT-15 cell growth | 0.20155681 | Sanger |
| DoTc2-4510 | Inhibition of human DoTc2-4510 cell growth | 1.475193253 | Sanger |
| CWR22R | Inhibition of human 22RV1 cell growth | 1.02806151 | Sanger |
| CAL-33 | Inhibition of human CAL-33 cell growth | 0.816624417 | Sanger |
| AGS | Inhibition of human AGS cell growth | 0.037531639 | Sanger |
| CAL-62 | Inhibition of human CAL-62 cell growth | 0.307520662 | Sanger |
| COR-L23 | Inhibition of human COR-L23 cell growth | 0.590666334 | Sanger |
| CW-2 | Inhibition of human CW-2 cell growth | 0.445867258 | Sanger |
| RKO | Inhibition of human RKO cell growth | 0.015174058 | Sanger |
| NMC-G1 | Inhibition of human NMC-G1 cell growth | 0.50459104 | Sanger |
| NCI-H292 | Inhibition of human NCI-H292 cell growth | 0.360234165 | Sanger |
| RD | Inhibition of human RD cell growth | 0.960313966 | Sanger |
| EW-7 | Inhibition of human EW-7 cell growth | 0.1668682 | Sanger |
| YH-13 | Inhibition of human YH-13 cell growth | 0.070594574 | Sanger |
| NCI-H1573 | Inhibition of human NCI-H1573 cell growth | 7.075371847 | Sanger |
| NOS-1 | Inhibition of human NOS-1 cell growth | 0.235162386 | Sanger |
| HD-MY-Z | Inhibition of human HD-MY-Z cell growth | 0.395228974 | Sanger |
| MDA-MB-453 | Inhibition of human MDA-MB-453 cell growth | 0.151883272 | Sanger |
| HuP-T3 | Inhibition of human HuP-T3 cell growth | 1.286118799 | Sanger |
| KM12 | Inhibition of human KM12 cell growth | 1.882498719 | Sanger |
| MDA-MB-175-VII | Inhibition of human MDA-MB-175-VII cell growth | 0.451194847 | Sanger |
| NCI-H1693 | Inhibition of human NCI-H1693 cell growth | 1.254767128 | Sanger |
| LCLC-103H cell line | Inhibition of human LCLC-103H cell growth | 0.210378708 | Sanger |
| NH-12 | Inhibition of human NH-12 cell growth | 0.172134006 | Sanger |
| HT55 | Inhibition of human HT55 cell growth | 0.65087218 | Sanger |
| HCC1937 | Inhibition of human HCC1937 cell growth | 1.638072097 | Sanger |
| HT-3 | Inhibition of human HT-3 cell growth | 0.192061048 | Sanger |
| NCI-H2291 | Inhibition of human NCI-H2291 cell growth | 20.98869585 | Sanger |
| M059J | Inhibition of human M059J cell growth | 1.304050253 | Sanger |
| SAOS-2 | Inhibition of human Saos-2 cell growth | 0.61268092 | Sanger |
| PC-14 | Inhibition of human PC-14 cell growth | 0.330629456 | Sanger |
| BEN | Inhibition of human BEN cell growth | 7.40830005 | Sanger |
| CFPAC-1 | Inhibition of human CFPAC-1 cell growth | 0.522059872 | Sanger |
| Capan-2 | Inhibition of human Capan-2 cell growth | 6.037318763 | Sanger |
| CGTH-W-1 | Inhibition of human CGTH-W-1 cell growth | 0.18597798 | Sanger |
| CHL-1 | Inhibition of human CHL-1 cell growth | 0.011895109 | Sanger |
| In vitro (25°C) | DMSO | 110 mg/mL (191.73 mM) | |
| Water | Insoluble | ||
| Ethanol | 4 mg/mL (6.97 mM) | ||
| In vivo | 30% propylene glycol, 5% Tween 80, 65% D5W | 28 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.43 mL | 87.15 mL | 174.31 mL |
| 0.5 mM | 3.49 mL | 17.43 mL | 34.86 mL |
| 1 mM | 1.74 mL | 8.72 mL | 17.43 mL |
| 5 mM | 0.35 mL | 1.74 mL | 3.49 mL |
*The above data is based on the productmolecular weight 573.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A10955 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 573.7 |
| Formula | C33H35NO6S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 877877-35-5 |
| Synonyms | TW37 |
| SMILES | CC(C)C1=CC=CC=C1CC2=C(C(=C(C(=C2)C(=O)NC3=CC=C(C=C3)S(=O)(=O)C4=CC=CC=C4C(C)(C)C)O)O)O |
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