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Tyrphostin AG 879是神经生长因子（NGF）TrkA酪氨酸激酶活性的抑制剂。
靶点信息
| HER2-Neu | Trk | PDGFR | EGFR | |
| 1.0 μM | 10 μM | >100 μM | >500 μM |
| In vitro (25°C) | DMSO | 35 mg/mL (110.59 mM) | |
| Water | Insoluble | ||
| Ethanol | 3 mg/mL (9.47 mM) | ||
| In vivo | 1% DMSO+30% polyethylene glycol+1% Tween 80 | 28 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 31.6 mL | 157.98 mL | 315.96 mL |
| 0.5 mM | 6.32 mL | 31.6 mL | 63.19 mL |
| 1 mM | 3.16 mL | 15.8 mL | 31.6 mL |
| 5 mM | 0.63 mL | 3.16 mL | 6.32 mL |
*The above data is based on the productmolecular weight 316.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A10053 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 316.5 |
| Formula | C18H24N2OS |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 148741-30-4 |
| Synonyms | AG879 |
| SMILES | CC(C)(C)C1=CC(=C/C(=C(/N)\S)/C#N)C=C(C1=O)C(C)(C)C |
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