产品详情

生物活性

UNC0642是有效的选择性G9a和GLP组蛋白赖氨酸甲基转移酶抑制剂（IC50 <2.5 nM）。它降低了MDA-MB-231细胞中的H3K9二甲基化水平（IC50 = 110 nM）。在体内显示适度的大脑渗透。

溶解度 *

In vitro	DMSO	88 mg/mL (160.96 mM)
	Water	Insoluble
	Ethanol	88 mg/mL (160.96 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.29 mL	91.46 mL	182.92 mL
0.5 mM	3.66 mL	18.29 mL	36.58 mL
1 mM	1.83 mL	9.15 mL	18.29 mL
5 mM	0.37 mL	1.83 mL	3.66 mL

*The above data is based on the productmolecular weight 546.69. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A15487
作用机制	Inhibitor (抑制剂)
M. Wt	546.69
Formula	C29H44F2N6O2
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1481677-78-4
Synonyms	UNC 0642, UNC-0642
SMILES	CC(C)N1CCC(CC1)NC2=NC(=NC3=CC(=C(C=C32)OC)OCCCN4CCCC4)N5CCC(CC5)(F)F