Upadacitinib (ABT-494)

Name: Upadacitinib (ABT-494)
SKU: A18316
Price: 210 CNY
Rating: 5 (288 reviews)

目录号: A18316

JAK1 抑制剂

Upadacitinib (ABT-494) 是一种强效且选择性的 Janus 激酶（JAK）1 抑制剂，正在开发中，用于治疗多种自身免疫性疾病，其半抑制浓度（IC50）为 43 nM。IC50 & 目标：IC50：43 nM（JAK1），200 nM（JAK2）

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Grouped product items
规格	价格	库存
1mg	¥210.00	现货
2mg	¥315.00	现货
5mg	¥595.00	现货
10mg	¥875.00	现货
25mg	¥1,575.00	现货
50mg	¥2,205.00	现货
100mg	¥3,150.00	现货
200mg	¥4,830.00	现货
500mg	¥8,575.00	现货
*10mM 1mL in DMSO**	¥245.00	现货
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Data Sheet

SDS

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生物活性

Discription

Upadacitinib (ABT-494) is a potent and selective Janus kinase (JAK) 1 inhibitor being developed for the treatment of several autoimmune disorders with an IC50 of 43 nM. IC50 & Target: IC50: 43 nM (JAK1), 200 nM (JAK2)

Targets

Target	Value

产品信息

目录号	A18316
分子式	C17H19F3N6O
分子量	380.37
CAS号	1310726-60-3
SMILES	CCC1CN(CC1C2=CN=C3N2C4=C(NC=C4)N=C3)C(=O)NCC(F)(F)F
其他名称	ABT 494, ABT494
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	66 mg/mL (173.51 mM)
	Water	Insoluble
	Ethanol	66 mg/mL (173.51 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.29 mL	131.45 mL	262.9 mL
0.5 mM	5.26 mL	26.29 mL	52.58 mL
1 mM	2.63 mL	13.15 mL	26.29 mL
5 mM	0.53 mL	2.63 mL	5.26 mL

Useful Calculator

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Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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