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Valproic acid is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2; Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 69.34 mL | 346.72 mL | 693.43 mL |
| 0.5 mM | 13.87 mL | 69.34 mL | 138.69 mL |
| 1 mM | 6.93 mL | 34.67 mL | 69.34 mL |
| 5 mM | 1.39 mL | 6.93 mL | 13.87 mL |
*The above data is based on the productmolecular weight 144.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A17323 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 144.21 |
| Formula | C8H16O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 99-66-1 |
| Synonyms | Valproic acid; Depakin; Erganyl; Stavzor; Valproate |
| SMILES | CCCC(CCC)C(O)=O |
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