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VcMMAE是一种抗体-药物偶联物（ADC），通过使用抗核分裂剂单甲基auristatin E（MMAE）（通过溶酶体可裂解的二肽缬氨酸-瓜氨酸（vc）连接），具有强大的抗肿瘤活性。
| In vitro | DMSO | 92 mg/mL (69.87 mM) | |
| Water | Insoluble | ||
| Ethanol | 92 mg/mL (69.87 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 7.6 mL | 37.98 mL | 75.95 mL |
| 0.5 mM | 1.52 mL | 7.6 mL | 15.19 mL |
| 1 mM | 0.76 mL | 3.8 mL | 7.6 mL |
| 5 mM | 0.15 mL | 0.76 mL | 1.52 mL |
*The above data is based on the productmolecular weight 1316.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A14362 |
|---|---|
| M. Wt | 1316.63 |
| Formula | C68H105N11O15 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 646502-53-6 |
| Synonyms | Vedotin |
| SMILES | CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@@H]([C@@H](C)C(=O)N[C@H](C)[C@H](C2=CC=CC=C2)O)OC)OC)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)N(C)C(=O)OCC3=CC=C(C=C3)NC(=O)[C@H](CCCNC(=O)N)NC(=O)[C@H](C(C)C)NC(=O)CCCCCN4C(=O)C=CC4=O |
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