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Vorinostat (SAHA)是HDAC的抑制剂，抑制脱乙酰和导致双方超乙酰化组蛋白和转录因子的积累。
靶点信息
| HDAC (Cell-free assay) | ||||
| ~10 nM |
| In vitro (25°C) | DMSO | 49 mg/mL (185.39 mM) | |
| Water | Insoluble | ||
| Ethanol | 3 mg/mL (11.35 mM) | ||
| In vivo | 2% DMSO+30% PEG 300+5% Tween 80+ddH2O | 4 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 37.84 mL | 189.18 mL | 378.36 mL |
| 0.5 mM | 7.57 mL | 37.84 mL | 75.67 mL |
| 1 mM | 3.78 mL | 18.92 mL | 37.84 mL |
| 5 mM | 0.76 mL | 3.78 mL | 7.57 mL |
*The above data is based on the productmolecular weight 264.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A10979 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 264.3 |
| Formula | C14H20N2O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 149647-78-9 |
| Synonyms | Zolinza, MK-0683 |
| SMILES | C1=CC=C(C=C1)NC(=O)CCCCCCC(=O)NO |
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