产品详情

生物活性

VR23是一个小分子，可有效抑制胰蛋白酶样蛋白酶体（IC50 = 1 nM），胰凝乳蛋白酶样蛋白酶体（IC50 = 50-100 nM）和半胱天冬酶样蛋白酶体（IC50 = 3uM）的活性。

靶点信息

Trypsin-like proteasomes	Chymotrypsin-like proteasomes	Caspase-like proteasomes
1 nM	50-100 nM	3 μM

溶解度 *

In vitro	DMSO	Warmed: 29 mg/mL (60.68 mM)
	Water	Warmed: 5 mg/mL (10.46 mM)
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.93 mL	104.63 mL	209.26 mL
0.5 mM	4.19 mL	20.93 mL	41.85 mL
1 mM	2.09 mL	10.46 mL	20.93 mL
5 mM	0.42 mL	2.09 mL	4.19 mL

*The above data is based on the productmolecular weight 477.88. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A13650
作用机制	Inhibitor (抑制剂)
M. Wt	477.88
Formula	C19H16ClN5O6S
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1624602-30-7
Synonyms	VR-23, VR 23
SMILES	ClC1=CC2=C(C(N3CCN(S(C4=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C4)(=O)=O)CC3)=CC=N2)C=C1