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VU 0357121是代谢型谷氨酸受体5（mGlu5）的正变构调节剂（PAM），EC50 = 33 nM，Glumax为92％。
靶点信息
| mGluR5 | ||||
| 30 nM(EC50) |
| In vitro | DMSO | 56 mg/mL (183.41 mM) | |
| Water | Insoluble | ||
| Ethanol | 19 mg/mL (62.23 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 32.75 mL | 163.77 mL | 327.55 mL |
| 0.5 mM | 6.55 mL | 32.75 mL | 65.51 mL |
| 1 mM | 3.28 mL | 16.38 mL | 32.75 mL |
| 5 mM | 0.66 mL | 3.28 mL | 6.55 mL |
*The above data is based on the productmolecular weight 305.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11754 |
|---|---|
| M. Wt | 305.3 |
| Formula | C17H17F2NO2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 433967-28-3 |
| Synonyms | VU0357121,VU-0357121 |
| SMILES | CCCCOC1=CC=C(C=C1)C(=O)NC2=C(C=C(C=C2)F)F |
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