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VU 0361737是mGluR-4的选择性正变构调节剂（人和大鼠受体的EC50值分别为240和110 nM）。
靶点信息
| mGluR4 (Rat ) | mGluR4 (Human) | |||
| 110 nM(EC50) | 240 nM(EC50) |
| In vitro | DMSO | 52 mg/mL (197.94 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 38.07 mL | 190.34 mL | 380.68 mL |
| 0.5 mM | 7.61 mL | 38.07 mL | 76.14 mL |
| 1 mM | 3.81 mL | 19.03 mL | 38.07 mL |
| 5 mM | 0.76 mL | 3.81 mL | 7.61 mL |
*The above data is based on the productmolecular weight 262.69. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A12467 |
|---|---|
| 作用机制 | Modulator (调节剂) |
| M. Wt | 262.69 |
| Formula | C13H11ClN2O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1161205-04-4 |
| Synonyms | VU-0361737, VU0361737 |
| SMILES | COC1=C(C=CC(=C1)NC(=O)C2=CC=CC=N2)Cl |
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