VX-680 (MK-0457, Tozasertib)

Name: VX-680 (MK-0457, Tozasertib)
SKU: A10981
Price: 280 CNY
Rating: 5 (3 reviews)

目录号: A10981

Aurora Kinase 抑制剂

3 篇发表文献

VX-680 是一种强效且选择性的小分子Aurora激酶抑制剂。

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Grouped product items
规格	价格	库存
25mg	¥280.00	现货
50mg	¥420.00	现货
100mg	¥700.00	现货
250mg	¥1,400.00	现货
*10mM 1mL in DMSO**	¥315.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用VX-680 (MK-0457, Tozasertib)发表的3篇文献

Helen E. Grimsley, .et al. , bioRxiv, 2024, Jan 23

Sakamoto K, .et al. , Leukemia, 2018, May 23 PMID: 29795241

W. Joost Lesterhuis, .et al. , Sci Rep, 2015, 5: 12298 PMID: 26193793

生物活性

Discription

VX-680 is a potent and selective small-molecule inhibitor of the Aurora kinases.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A10981
分子式	C23H28N8OS
分子量	464.6
CAS号	639089-54-6
SMILES	CC1=CC(=NN1)NC2=NC(=NC(=C2)N3CCN(CC3)C)SC4=CC=C(C=C4)NC(=O)C5CC5
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	90 mg/mL (193.71 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+30% PEG 300+2% Tween 80+ddH2O	14 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.52 mL	107.62 mL	215.24 mL
0.5 mM	4.3 mL	21.52 mL	43.05 mL
1 mM	2.15 mL	10.76 mL	21.52 mL
5 mM	0.43 mL	2.15 mL	4.3 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

Calculate Reset

* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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