VX-765 (Belnacasan)

Name: VX-765 (Belnacasan)
SKU: A10984
Price: 175 CNY
Rating: 5 (8 reviews)

目录号: A10984

Caspase-1/4 抑制剂

8 篇发表文献

VX-765 是一种新型的 Caspase-1 抑制剂，这是一种控制两种细胞因子，IL-1b 和 IL-18 生成的酶。

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Grouped product items
规格	价格	库存
2mg	¥175.00	现货
5mg	¥280.00	现货
10mg	¥490.00	现货
25mg	¥1,155.00	现货
50mg	¥1,680.00	现货
100mg	¥2,765.00	现货
200mg	¥4,480.00	现货
*10mM 1mL in DMSO**	¥315.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用VX-765 (Belnacasan)发表的8篇文献

Joseph Flores, .et al. , Cell Death Dis, 2022, Oct 11;13(10):864 PMID: 36220815

Arjun Thapa, .et al. , Leukemia, 2021, 23 February

Prenitha Mercy Ignatius Arokia Doss, .et al. , Cell Rep, 2021, Mar 9;34(10):108833 PMID: 33691111

Joseph Flores, .et al. , Nat Commun, 2020, Sep 11;11(1):4571 PMID: 32917871

Joseph Flores, .et al. , Nat Commun, 2018, 9: 3916 PMID: 30254377

Mohamed F. Ali, .et al. , Front Immunol, 2017, 8: 1504 PMID: 29170665

García-Fernández A, .et al. , J Control Release, 2017, Feb 28;248:60-70 PMID: 28069553

Jiujiu Yu, .et al. , Proc Natl Acad Sci U S A, 2014, 111(43): 15514-15519 PMID: 25313054

生物活性

Discription

VX-765 is a novel Caspase-1 inhibitor,which is an enzyme that controls the generation of two cytokines, IL-1b and IL-18.

Targets

Target	Value

产品信息

目录号	A10984
分子式	C24H33ClN4O6
分子量	509
CAS号	273404-37-8
SMILES	CCO[C@H]1[C@H](CC(=O)O1)NC(=O)[C@@H]2CCCN2C(=O)[C@H](C(C)(C)C)NC(=O)C3=CC(=C(C=C3)N)Cl
其他名称	VX765
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	Warmed: 87 mg/mL (170.92 mM)
	Water	Insoluble
	Ethanol	Warmed: 87 mg/mL (170.92 mM)
In vivo	2% DMSO+30% PEG 300+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.65 mL	98.23 mL	196.46 mL
0.5 mM	3.93 mL	19.65 mL	39.29 mL
1 mM	1.96 mL	9.82 mL	19.65 mL
5 mM	0.39 mL	1.96 mL	3.93 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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