VX-770 (Ivacaftor)

Name: VX-770 (Ivacaftor)
SKU: A10985

目录号: A10985

CFTR activator

Product Citations (1)

VX-770 (Ivacaftor) Chemical Structure

CAS NO. 873054-44-5, 121911-71-5

VX-770 (Ivacaftor)被称为CFTR增强剂，靶向作用于G551D-CFTR和F508del-CFTR，在fisher大鼠甲状腺细胞中EC50分别为100 nM和25 nM。

库存：现货

规格	价格	数量
5 mg	￥ 490.00
10 mg	￥ 840.00
50 mg	￥ 2,660.00
100 mg	￥ 4,550.00

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生物活性

VX-770 (Ivacaftor)被称为CFTR增强剂，靶向作用于G551D-CFTR和F508del-CFTR，在fisher大鼠甲状腺细胞中EC50分别为100 nM和25 nM。

靶点信息

F508del-CFTR (Fisher rat thyroid cells)	G551D-CFTR (Fisher rat thyroid cells)
25 nM(EC50)	100 nM(EC50)

溶解度 *

In vitro	DMSO	69 mg/mL (175.8 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.48 mL	127.39 mL	254.78 mL
0.5 mM	5.1 mL	25.48 mL	50.96 mL
1 mM	2.55 mL	12.74 mL	25.48 mL
5 mM	0.51 mL	2.55 mL	5.1 mL

*The above data is based on the productmolecular weight 392.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10985
作用机制	Activator (激活剂)
M. Wt	392.5
Formula	C24H28N2O3
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	873054-44-5, 121911-71-5
Synonyms	Kalydeco, VX770
SMILES	CC(C)(C)C1=CC(=C(C=C1NC(=O)C2=CNC3=CC=CC=C3C2=O)O)C(C)(C)C