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VZ185 is a potent, fast, and selective dual BRD7/9 PROTAC degrader with DC50s of 4.5 and 1.8 nM, respectively.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 10.05 mL | 50.24 mL | 100.48 mL |
| 0.5 mM | 2.01 mL | 10.05 mL | 20.1 mL |
| 1 mM | 1 mL | 5.02 mL | 10.05 mL |
| 5 mM | 0.2 mL | 1 mL | 2.01 mL |
*The above data is based on the productmolecular weight 995.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A18685 |
|---|---|
| 作用机制 | Degrader (降解剂) |
| M. Wt | 995.21 |
| Formula | C53H67FN8O8S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 2306193-61-1 |
| Synonyms | VZ-185, VZ 185 |
| SMILES | O=C([C@H]1N(C([C@@H](NC(C2(F)CC2)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC3=CC=C(C4=C(C)N=CS4)C=C3OCCCCCN5CCN(CC6=C(OC)C=C(C(C7=CC=NC=C87)=CN(C)C8=O)C=C6OC)CC5 |
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