Withaferin A
Withaferin A 是存在于 W. somnifera 中的一种甾体内酯，在2-25 μM 的浓度下，已被证实能够与培养的内皮细胞和成纤维细胞中的 vimentin 中间丝 结合并诱导其聚集，从而引发细胞凋亡。
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Adooq用户使用Withaferin A发表的1篇文献
生物活性
| Discription | Withaferin A is a steroidal lactone present in W. somnifera that at 2-25 μM has been shown to bind to and induce aggregation of vimentin intermediate filaments in cultured endothelial cells and fibroblasts, causing apoptosis. | |||||
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产品信息
| 目录号 | A16904 |
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| 分子式 | C28H38O6 |
| 分子量 | 470.6 |
| CAS号 | 5119-48-2 |
| SMILES | O=C/1O[C@H](CC(=C\1CO)\C)[C@@H](C)[C@H]6CC[C@@H]4[C@]6(C)CC[C@@H]3[C@]5(C(=O)\C=C/[C@H](O)[C@]52O[C@@H]2C[C@H]34)C |
| 其他名称 | WithaferinA, Withaferin-A, NSC 101088, NSC 273757 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | 92 mg/mL (195.49 mM) | |
| Water | Insoluble | ||
| Ethanol | 4 mg/mL (8.49 mM) | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.25 mL | 106.25 mL | 212.49 mL |
| 0.5 mM | 4.25 mL | 21.25 mL | 42.5 mL |
| 1 mM | 2.12 mL | 10.62 mL | 21.25 mL |
| 5 mM | 0.42 mL | 2.12 mL | 4.25 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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| 购买 5119-48-2 | 5119-48-2 供应商 | 5119-48-2 花费 | 5119-48-2 生产商 | 订购 5119-48-2 | 5119-48-2 代理商