WP1130 (Degrasyn)

Name: WP1130 (Degrasyn)
SKU: A10988
Price: 350 CNY
Rating: 5 (1 reviews)

目录号: A10988

DUB/Bcr/ABL 抑制剂

1 篇发表文献

WP1130（Degrasyn）是一种新型选择性小分子去泛素化酶抑制剂，同时也是一种Bcr/Abl降解途径激活剂，能够特异性且迅速地降低慢性髓性白血病（CML）细胞中野生型和突变型Bcr/Abl蛋白的表达，而不影响bcr/abl基因的表达。

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Grouped product items
规格	价格	库存
5mg	¥350.00	现货
10mg	¥665.00	现货
25mg	¥1,400.00	现货
50mg	¥1,925.00	现货
100mg	¥3,115.00	现货
*10mM 1mL in DMSO**	¥385.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用WP1130 (Degrasyn)发表的1篇文献

Kevin Bohm, .et al. , Arch Pharm (Weinheim), 2023, Jul;356(7):e2200661 PMID: 37196427

生物活性

Discription

WP1130 (Degrasyn) is a novel selective small molecular deubiquitinase inhibitor and a Bcr/Abl destruction pathway activator that specifically and rapidly down-regulates both wild-type and mutant Bcr/Abl protein without affecting bcr/abl gene expression in chronic myelogenous leukemia (CML) cells.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A10988
分子式	C19H18BrN3O
分子量	384.3
CAS号	856243-80-6
SMILES	CCC[C@@H](C1=CC=CC=C1)NC(=O)/C(=C/C2=NC(=CC=C2)Br)/C#N
其他名称	WP-1130, Degrasyn
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	73 mg/mL (189.96 mM)
	Water	Insoluble
	Ethanol	17 mg/mL (44.24 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.02 mL	130.11 mL	260.21 mL
0.5 mM	5.2 mL	26.02 mL	52.04 mL
1 mM	2.6 mL	13.01 mL	26.02 mL
5 mM	0.52 mL	2.6 mL	5.2 mL

Useful Calculator

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Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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