WYE-125132 (WYE-132)

Name: WYE-125132 (WYE-132)
SKU: A11038

目录号: A11038

mTOR 抑制剂

WYE-125132 (WYE-132) Chemical Structure

CAS NO. 1144068-46-1

WYE-125132 (WYE-132)是一种高度有效的，ATP竞争性的mTOR抑制剂，IC50为0.19 nM；作用于mTOR比作用于PI3Ks或PI3K相关激酶hSMG1和ATR选择性高。

库存：现货

规格	价格	数量
5 mg	￥ 840.00
10 mg	￥ 1,400.00
50 mg	￥ 5,040.00
100 mg	￥ 8,400.00
10mM * 1mL in DMSO	￥ 945.00

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生物活性

WYE-125132 (WYE-132)是一种高度有效的，ATP竞争性的mTOR抑制剂，IC50为0.19 nM；作用于mTOR比作用于PI3Ks或PI3K相关激酶hSMG1和ATR选择性高。

靶点信息

mTOR
0.19 nM

溶解度 *

In vitro (25°C)	DMSO	95 mg/mL (182.83 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.25 mL	96.23 mL	192.46 mL
0.5 mM	3.85 mL	19.25 mL	38.49 mL
1 mM	1.92 mL	9.62 mL	19.25 mL
5 mM	0.38 mL	1.92 mL	3.85 mL

*The above data is based on the productmolecular weight 519.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11038
作用机制	Inhibitor (抑制剂)
M. Wt	519.6
Formula	C27H33N7O4
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1144068-46-1
Synonyms	WYE125132, WYE-132, WYE132
SMILES	CNC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=NN3C4CCC5(CC4)OCCO5)C(=N2)N6CC7CCC(C6)O7