WYE-354

Name: WYE-354
SKU: A10989
Price: 245 CNY
Rating: 5 (1 reviews)

目录号: A10989

mTOR 抑制剂

1 篇发表文献

WYE-354 是一种强效的细胞渗透性 mTOR 抑制剂（IC50 = 4.3 nM），能够阻断通过 mTOR 复合体 1 (mTORC1) 和 mTOR 复合体 2 (mTORC2) 的信号传导。它对 PI3K α 的抑制作用较弱（IC50 = 1026 nM），对其他激酶的抑制作用也较弱。

Skip to the end of the images gallery

Skip to the beginning of the images gallery

Grouped product items
规格	价格	库存
5mg	¥245.00	现货
10mg	¥455.00	现货
25mg	¥1,050.00	现货
50mg	¥2,030.00	现货
100mg	¥2,625.00	现货
*10mM 1mL in DMSO**	¥280.00	现货
更大包装	更多折扣

大包装询价

Notify me when the price drops

全国免运费, 顺丰次日达

重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用WYE-354发表的1篇文献

H Weber ,etc. Rapamycin and WYE-354 suppress human gallbladder cancer xenografts in mice. Oncotarget, 2015, 6(31), 31877.

生物活性

Discription

WYE-354 is a potent cell-permeable inhibitor of mTOR (IC50 = 4.3 nM) which blocks signaling through both mTOR complex 1 (mTORC1) and mTORC2. It is a much weaker inhibitor of PI3K α (IC50 = 1026 nM) and other kinases.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A10989
分子式	C24H29N7O5
分子量	495.5
CAS号	1062169-56-5
SMILES	COC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=NN3C4CCN(CC4)C(=O)OC)C(=N2)N5CCOCC5
其他名称	WYE354
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	95 mg/mL (191.71 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	4% DMSO+30% PEG 300+5% Tween 80+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.18 mL	100.91 mL	201.82 mL
0.5 mM	4.04 mL	20.18 mL	40.36 mL
1 mM	2.02 mL	10.09 mL	20.18 mL
5 mM	0.4 mL	2.02 mL	4.04 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

Calculate Reset

* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Keywords: 购买 WYE-354 | WYE-354 供应商 | WYE-354 花费 | WYE-354 生产商 | 订购 WYE-354 | WYE-354 代理商 | 购买 1062169-56-5 | 1062169-56-5 供应商 | 1062169-56-5 花费 | 1062169-56-5 生产商 | 订购 1062169-56-5 | 1062169-56-5 代理商