产品详情

生物活性

WZ811是4型C-X-C趋化因子受体（CXCR4）拮抗剂（EC50 = 0.3 nM）。在体外抑制CXCR4/基质细胞衍生因子1（SDF-1）介导的cAMP调节（EC50 = 1.2 nM）。

靶点信息

CXCR4
0.3 nM(EC50)

溶解度 *

In vitro	DMSO	29 mg/mL (99.88 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	34.44 mL	172.2 mL	344.4 mL
0.5 mM	6.89 mL	34.44 mL	68.88 mL
1 mM	3.44 mL	17.22 mL	34.44 mL
5 mM	0.69 mL	3.44 mL	6.89 mL

*The above data is based on the productmolecular weight 290.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A12588
作用机制	Antagonist (拮抗剂)
M. Wt	290.36
Formula	C18H18N4
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	55778-02-4
Synonyms	WZ811; WZ-811; WZ 811.
SMILES	C1=CC=NC(=C1)NCC2=CC=C(C=C2)CNC3=CC=CC=N3