X-376

Name: X-376
SKU: A20971
Price: 175 CNY
Rating: 5 (288 reviews)

目录号: A20971

ALK 抑制剂

X-376 是一种强效且高度特异性的 ALK 酪氨酸激酶抑制剂（TKI）（IC50=0.61 nM）。X-376 对 MET 的抑制作用较弱（IC50=0.69 nM）。X-376 表现出强大的抗肿瘤活性。

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Grouped product items
规格	价格	库存
1mg	¥175.00	现货
2mg	¥245.00	现货
5mg	¥560.00	现货
10mg	¥805.00	现货
25mg	¥1,855.00	现货
50mg	¥3,115.00	现货
100mg	¥4,235.00	现货
*10mM 1mL in DMSO**	¥700.00	现货
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Data Sheet

SDS

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生物活性

Discription

X-376 is a potent and highly specific ALK tyrosine kinase inhibitor (TKI) (IC50=0.61 nM). X-376 is a less potent inhibitor of MET (IC50=0.69 nM). X-376 displays potent anti-tumor activity.

Targets

Target	Value

产品信息

目录号	A20971
分子式	C25H25Cl2FN6O3
分子量	547.41
CAS号	1365267-27-1
SMILES	O=C(C1=NN=C(N)C(O[C@@H](C2=C(Cl)C=CC(F)=C2Cl)C)=C1)NC3=CC=C(C(N4CCN(C)CC4)=O)C=C3
其他名称	X376, X 376
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	94 mg/mL (171.71 mM)
	Water	Insoluble
	Ethanol	12 mg/mL (21.91 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.27 mL	91.34 mL	182.68 mL
0.5 mM	3.65 mL	18.27 mL	36.54 mL
1 mM	1.83 mL	9.13 mL	18.27 mL
5 mM	0.37 mL	1.83 mL	3.65 mL

Useful Calculator

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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