产品详情

生物活性

XL888是口服可生物利用的，具有ATP竞争性的小分子热休克蛋白90（Hsp90）抑制剂，IC50为24 nM。具有潜在的抗肿瘤活性。

靶点信息

HSP90
24 nM

溶解度 *

In vitro (25°C)	DMSO	99 mg/mL (196.56 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.86 mL	99.28 mL	198.56 mL
0.5 mM	3.97 mL	19.86 mL	39.71 mL
1 mM	1.99 mL	9.93 mL	19.86 mL
5 mM	0.4 mL	1.99 mL	3.97 mL

*The above data is based on the productmolecular weight 503.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11251
作用机制	Inhibitor (抑制剂)
M. Wt	503.63
Formula	C29H37N5O3
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1149705-71-4
Synonyms	XL888; XL-888; XL 888
SMILES	CCC(C)NC1=CC(=C(C=C1C(=O)N)C)C(=O)NC2C[C@H]3CC[C@@H](C2)N3C4=NC=C(C=C4)C(=O)C5CC5