XL147 analogue

Name: XL147 analogue
SKU: A10995

目录号: A10995

PI3K 抑制剂

Product Citations (1)

XL147 analogue Chemical Structure

CAS NO. 956958-53-5

XL147 analogue是一种有效的，选择性的，口服可生物利用的I类磷脂酰肌醇3激酶（PI3K）小分子抑制剂，作用于PI3Kα/δ/γ，对PI3Kβ作用效果稍弱。具有潜在的抗肿瘤活性。

库存：现货

规格	价格	数量
10 mg	￥ 700.00
25 mg	￥ 1,400.00
50 mg	￥ 1,960.00
100 mg	￥ 3,360.00

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产品详情

生物活性

Targets

Target	Value
PI3Kγ	IC50: 23nM
PI3Kδ	IC50: 36nM
PI3Kα	IC50: 39nM
PI3Kβ	IC50: 383nM
DNA-PK	IC50: 4.75μM
Vps34	IC50: 6.975μM
MEK	IC50: >10μM
B-Raf/C-Raf	IC50: >10μM
mTOR	IC50: >15μM

溶解度 *

In vitro (25°C)	DMSO	3 mg/mL (6.68 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	14 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.3 mL	111.48 mL	222.97 mL
0.5 mM	4.46 mL	22.3 mL	44.59 mL
1 mM	2.23 mL	11.15 mL	22.3 mL
5 mM	0.45 mL	2.23 mL	4.46 mL

*The above data is based on the productmolecular weight 448.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10995
作用机制	Inhibitor (抑制剂)
M. Wt	448.5
Formula	C21H16N6O2S2
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	956958-53-5
Synonyms	XL-147, SAR245408
SMILES	CC1=CC=C(C=C1)S(=O)(=O)NC2=NC3=CC=CC=C3N=C2NC4=CC5=NSN=C5C=C4