XL184 free base (Cabozantinib)

Name: XL184 free base (Cabozantinib)
SKU: A10996
Price: 210 CNY
Rating: 5 (4 reviews)

目录号: A10996

VEGFR 抑制剂

4 篇发表文献

XL184 free base（Cabozantinib）是一种小分子药物，旨在抑制多种受体酪氨酸激酶，特别是 MET 和 VEGFR2。

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Grouped product items
规格	价格	库存
5mg	¥210.00	现货
10mg	¥350.00	现货
50mg	¥455.00	现货
100mg	¥630.00	现货
200mg	¥1,050.00	现货
500mg	¥1,785.00	现货
*10mM 1mL in DMSO**	¥245.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用XL184 free base (Cabozantinib)发表的4篇文献

Majid Momeny, .et al. , EMBO Mol Med, 2024, Jun 17 PMID: 38886591

Jhe-Cyuan Guo, .et al. , Journal of Clinical Oncology, 2024, May 29

Feyza Oflaz, .et al. , Cumhuriyet Sci. J., 2023, 44(4): 650-655

Fujita KI, .et al. , J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358

生物活性

Discription

XL184 free base (Cabozantinib) is a small molecule designed to inhibit multiple receptor tyrosine kinases, specifically MET and VEGFR2.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A10996
分子式	C28H24FN3O5
分子量	501.5
CAS号	849217-68-1
SMILES	COC1=CC2=C(C=CN=C2C=C1OC)OC3=CC=C(C=C3)NC(=O)C4(CC4)C(=O)NC5=CC=C(C=C5)F
其他名称	BMS-907351
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	92 mg/mL (183.44 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+30% PEG 300+5% Tween 80+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.94 mL	99.7 mL	199.4 mL
0.5 mM	3.99 mL	19.94 mL	39.88 mL
1 mM	1.99 mL	9.97 mL	19.94 mL
5 mM	0.4 mL	1.99 mL	3.99 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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