XL647 (Tesevatinib)
目录号: A11057
EGFR, HER2 and VEGFR 抑制剂
XL647 是一种口服生物利用度高的小分子 RTK 抑制剂,它能结合并抑制多种在肿瘤细胞增殖和肿瘤血管生成中起主要作用的酪氨酸受体激酶,包括 EGFR、HER2、ERBB2、VEGFR 和 EphB4。
Discription | XL647 is an orally bioavailable small-molecule RTK inhibitor that binds to and inhibits several tyrosine receptor kinases that play major roles in tumor cell proliferation and tumor vascularization, including EGFR, HER2, ERBB2, VEGFR and EphB4. | ||
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目录号 | A11057 |
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分子式 | C24H27Cl2FN4O2 |
分子量 | 493.4 |
CAS号 | 781613-23-8 |
SMILES | CN1CCCC(CCC1)COC2=C(C=C3C(=C2)N=CN=C3NC4=CC(=C(C(=C4)Cl)Cl)F)OC |
其他名称 | XL 647, XL-647, EXEL-7647 |
储存条件 | Store lyophilized at -20ºC, keep desiccated. |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2