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XL647 (Tesevatinib)是一种口服生物可利用的小分子RTK抑制剂，可结合并抑制在肿瘤细胞增殖和肿瘤血管形成中起主要作用的几种酪氨酸受体激酶，包括EGFR，HER2，ERBB2，VEGFR和EphB4。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.35 mL | 101.75 mL | 203.5 mL |
| 0.5 mM | 4.07 mL | 20.35 mL | 40.7 mL |
| 1 mM | 2.04 mL | 10.18 mL | 20.35 mL |
| 5 mM | 0.41 mL | 2.04 mL | 4.07 mL |
*The above data is based on the productmolecular weight 491.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11057 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 491.4 |
| Formula | C24H25Cl2FN4O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 874286-84-7 |
| Synonyms | XL 647, XL-647, EXEL-7647 |
| SMILES | CN1CCCC(CCC1)COC2=C(C=C3C(=C2)N=CN=C3NC4=CC(=C(C(=C4)Cl)Cl)F)OC |
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