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YL0919，具有5-HT1A受体激动剂和选择性5-羟色胺再摄取抑制剂双重活性的新型抗抑郁候选药物，YL-0919抑制5-HT被大鼠大脑皮层突触小体和人重组细胞摄取的IC50值为1.78±0.34 nM和1.93±0.18 nM。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 29.87 mL | 149.33 mL | 298.65 mL |
| 0.5 mM | 5.97 mL | 29.87 mL | 59.73 mL |
| 1 mM | 2.99 mL | 14.93 mL | 29.87 mL |
| 5 mM | 0.6 mL | 2.99 mL | 5.97 mL |
*The above data is based on the productmolecular weight 334.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A16337 |
|---|---|
| 作用机制 | Inhibitor (抑制剂), Agonist (激动剂) |
| M. Wt | 334.84 |
| Formula | C18H23N2O2Cl |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1339058-04-6 |
| Synonyms | YL-0919, YL 0919 |
| SMILES | O=C1C=CC=CN1CC2(O)CCN(CC3=CC=CC=C3)CC2.[H]Cl |
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