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YM155 (Sepantronium Bromide)

YM155 (Sepantronium Bromide)

Name: YM155 (Sepantronium Bromide)
SKU: A11002

目录号: A11002

Survivin 抑制剂

Product Citations (11)

Ali Nasrollahzadeh, .et al. Anti-proliferative activity of disulfiram through regulation of the AKT-FOXO axis: A proteomic study of molecular targets, Biochim Biophys Acta Mol Cell Res, 2021, Jun 26;1868(10):119087 PMID: 34182011
Chia-Hui Huang, .et al. Arsenic Trioxide-Induced p38 MAPK and Akt Mediated MCL1 Downregulation Causes Apoptosis of BCR-ABL1-positive Leukemia Cells, Toxicol Appl Pharmacol, 2020, Apr 17;397:115013 PMID: 32305283
Turner TH, .et al. Identification of synergistic drug combinations using breast cancer patient-derived xenografts, Sci Rep, 2020, Jan 30;10(1):1493 PMID: 32001757
Chiou JT, .et al. Autophagic HuR mRNA degradation induces survivin and MCL1 downregulation in YM155-treated human leukemia cells, Toxicol Appl Pharmacol, 2019, Dec 16;387:114857 PMID: 31837377
Hamzehlou S, .et al. Anti-tumor activity of neratinib, a pan-HER inhibitor, in gastric adenocarcinoma cells, Eur J Pharmacol, 2019, Nov 15;863:172705 PMID: 31574259
Momeny M, .et al. The ERBB receptor inhibitor dacomitinib suppresses proliferation and invasion of pancreatic ductal adenocarcinoma cells, Cell Oncol (Dordr), 2019, Apr 25 PMID: 31025257
Yamamoto M, .et al. AS602801 Sensitizes Ovarian Cancer Stem Cells to Paclitaxel by Down-regulating MDR1, Anticancer Res, 2019, Feb;39(2):609-617 PMID: 30711936
V??zquez-Mellado MJ, .et al. Erythropoietin promotes expression of survivin via STAT3 activation and reduces sensitivity to cisplatin in cervical cancer cells, Oncol Rep, 2018, Nov 27 PMID: 30483799
MASAHIRO YAMAMOTO, .et al. AS602801, an Anticancer Stem Cell Candidate Drug, Reduces Survivin Expression and Sensitizes A2780 Ovarian Cancer Stem Cells to Carboplatin and Paclitaxel, Anticancer Res, 2018, Dec 38 (12) 6699-6706 PMID: 30504379
Ahn MR, .et al. Both triazolyl ester of ketorolac (15K) and YM155 inhibit the embryonic angiogenesis in ovo (fertilized eggs) via their common PAK1-survivin/VEGF signaling pathway, Drug Discov Ther, 2017, 11(6):300-306 PMID: 29332887
MASAYA MINODA, .et al. Antitumor effect of YM155, a novel small-molecule survivin suppressant, via mitochondrial apoptosis in human MFH/UPS, Int J Oncol, 2015, Sep; 47(3): 891-899 PMID: 26166250

YM155 (Sepantronium Bromide) Chemical Structure

CAS NO. 781661-94-7

YM155 (Sepantronium Bromide)是一种新型小分子存活蛋白抑制剂，IC50为0.54 nM，可抑制存活蛋白启动子活性。

库存：现货

规格	价格	数量
5 mg	￥ 280.00
10 mg	￥ 490.00
25 mg	￥ 1,050.00
100 mg	￥ 2,800.00
10mM * 1mL in DMSO	￥ 350.00

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生物活性

YM155 (Sepantronium Bromide)是一种新型小分子存活蛋白抑制剂，IC50为0.54 nM，可抑制存活蛋白启动子活性。

靶点信息

Survivin (HeLa-SURP-luc, CHO-SV40-luc cells)
0.54 nM

溶解度 *

In vitro (25°C)	DMSO	52 mg/mL (117.3 mM)
	Water	85 mg/mL (191.75 mM)
	Ethanol	6 mg/mL (13.53 mM)
In vivo	Saline	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.56 mL	112.79 mL	225.58 mL
0.5 mM	4.51 mL	22.56 mL	45.12 mL
1 mM	2.26 mL	11.28 mL	22.56 mL
5 mM	0.45 mL	2.26 mL	4.51 mL

*The above data is based on the productmolecular weight 443.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11002
作用机制	Inhibitor (抑制剂)
M. Wt	443.3
Formula	C20H19BrN4O3
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	781661-94-7
SMILES	CC1=[N+](C2=C(N1CCOC)C(=O)C3=CC=CC=C3C2=O)CC4=NC=CN=C4.[Br-]