YO-01027

Name: YO-01027
SKU: A11174

目录号: A11174

γ-secretase 抑制剂

YO-01027 Chemical Structure

CAS NO. 209984-56-5

YO-01027是一种二肽γ-secretase抑制剂，作用于APPL和Notch分裂，无细胞试验中IC50分别为2.6 nM和2.9 nM，一种抗阿尔茨海默氏病药物。

库存：现货

规格	价格	数量
5 mg	￥ 560.00
10 mg	￥ 980.00
25 mg	￥ 2,240.00
50 mg	￥ 3,640.00
10mM * 1mL in DMSO	￥ 560.00

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生物活性

YO-01027是一种二肽γ-secretase抑制剂，作用于APPL和Notch分裂，无细胞试验中IC50分别为2.6 nM和2.9 nM，一种抗阿尔茨海默氏病药物。

靶点信息

γ secretase(APPL) (Cell-free assay)	γ secretase(Notch) (Cell-free assay)
2.6 nM	2.9 nM

溶解度 *

In vitro (25°C)	DMSO	87 mg/mL (187.7 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	0.5% hydroxyethyl cellulose	5 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.58 mL	107.88 mL	215.76 mL
0.5 mM	4.32 mL	21.58 mL	43.15 mL
1 mM	2.16 mL	10.79 mL	21.58 mL
5 mM	0.43 mL	2.16 mL	4.32 mL

*The above data is based on the productmolecular weight 463.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11174
作用机制	Inhibitor (抑制剂)
M. Wt	463.48
Formula	C26H23F2N3O3
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	209984-56-5
Synonyms	YO01027, Dibenzazepine, Deshydroxy LY 411575
SMILES	C[C@@H](C(=O)N[C@H]1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)NC(=O)CC4=CC(=CC(=C4)F)F