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ZM 39923 HCl是JAK3抑制剂（IC50 = 79 nM），其抑制表皮生长因子受体，JAK1和细胞周期蛋白依赖性激酶4（IC50s分别为2.4、40和10 M）的抑制作用较小。
靶点信息
| TGM2 | JAK3 | EGFR | JAK1 | |
| 10 nM | 7.1(pIC50) | 5.6(pIC50) | 4.4(pIC50) |
| In vitro | DMSO | 26 mg/mL (70.67 mM) | |
| Water | Insoluble | ||
| Ethanol | 7 mg/mL (19.02 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 27.18 mL | 135.91 mL | 271.81 mL |
| 0.5 mM | 5.44 mL | 27.18 mL | 54.36 mL |
| 1 mM | 2.72 mL | 13.59 mL | 27.18 mL |
| 5 mM | 0.54 mL | 2.72 mL | 5.44 mL |
*The above data is based on the productmolecular weight 367.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A13509 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 367.9 |
| Formula | C23H25NOHCl |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1021868-92-7 |
| Synonyms | JAK3 Inhibitor IV |
| SMILES | O=C(CCN(CC1=CC=CC=C1)C(C)C)C2=CC3=CC=CC=C3C=C2.Cl |
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