ZM-447439

Name: ZM-447439
SKU: A11009

目录号: A11009

Aurora Kinase 抑制剂

ZM-447439 Chemical Structure

CAS NO. 331771-20-1

ZM 447439是Aurora A和Aurora B的选择性和ATP竞争性抑制剂，IC50分别为110 nM和130 nM。它对Aurora A/B的选择性是MEK1，Src，Lck的8倍以上，对CDK1/2/4，Plk1，Chk1等的影响很小。

库存：现货

规格	价格	数量
5 mg	￥ 280.00
10 mg	￥ 490.00
25 mg	￥ 1,050.00
50 mg	￥ 1,820.00
10mM * 1mL in DMSO	￥ 700.00

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产品详情

生物活性

Targets

Target	Value
AuroraA	IC50: 110nM
AuroraB	IC50: 130nM
LCK	IC50: 880nM
Src	IC50: 1.03μM
MEK1	IC50: 1.79μM
CDK1	IC50: >10μM
CDK2	IC50: >10μM
CDK4	IC50: >10μM
PLK1	IC50: >10μM
Chk1	IC50: >10μM
IKK1	IC50: >10μM
IKK2	IC50: >10μM
cFLT2	IC50: >10μM
KDR2	IC50: >10μM
ZAP70	IC50: >10μM
FAK	IC50: >10μM

溶解度 *

In vitro (25°C)	DMSO	90 mg/mL (175.23 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.47 mL	97.35 mL	194.7 mL
0.5 mM	3.89 mL	19.47 mL	38.94 mL
1 mM	1.95 mL	9.74 mL	19.47 mL
5 mM	0.39 mL	1.95 mL	3.89 mL

*The above data is based on the productmolecular weight 513.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11009
作用机制	Inhibitor (抑制剂)
M. Wt	513.6
Formula	C29H31N5O4
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	331771-20-1
Synonyms	ZM447439
SMILES	COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=C(C=C3)NC(=O)C4=CC=CC=C4)OCCCN5CCOCC5