DHFR

Inhibitory Selectivity

Catalog No.	Inhibitor Name	DHFR	Other
A10707	Pemetrexed	****	TS,GARFT
A15207	Pemetrexed Disodium Hydrate	****	TS,GARFT
A10021	Methotrexate
A11522	Pralatrexate

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Quick View
Methotrexate (Abitrexate)

Catalog No. A10021
Quick View

添加到收藏
DHFR 抑制剂

Methotrexate (Abitrexate)是一种抑制胸苷酸合成酶和从头嘌呤合成的细胞毒剂。了解更多

Bulk Inquiry Free Sample
Quick View
Pemetrexed

Catalog No. A12668
Quick View

添加到收藏
DHFR 抑制剂

Pemetrexed 是一种具有多个靶标的新型抗叶酸药。作用于TS，DHFR和GARFT，Ki分别为1.3 nM，7.2 nM 和 65 nM。了解更多

Bulk Inquiry
Quick View
NSC 131463 (DAMPA)

Catalog No. A10655
Quick View

添加到收藏
DHFR 抑制剂

NSC 131463 (DAMPA)是有效的二氢叶酸还原酶抑制剂，IC50为1 nM。了解更多

Bulk Inquiry
Quick View
Pralatrexate

Catalog No. A11522
Quick View

添加到收藏
DHFR 抑制剂

Pralatrexate是一种抗叶酸剂(叶酸类似物代谢抑制剂),设计用于优先在癌细胞中积累。了解更多

Bulk Inquiry Free Sample
Quick View
Diaveridine

Catalog No. A17000
Quick View

添加到收藏
DHFR 抑制剂

Diaveridine（EGIS-5645）是一种二氢叶酸还原酶（DHFR）抑制剂，其野生型DHFR的Ki值为11.5 nM，同时也是一种抗菌剂。了解更多

Bulk Inquiry
Quick View
WR99210

Catalog No. A18837
Quick View

添加到收藏
DHFR 抑制剂

WR99210 is a effective inhibitor of dihydrofolate reductase (DHFR) with an IC50 of <0.075 nM. WR99210 is effective against the most pyrimethamine-resistant Plasmodium falciparum strains. 了解更多

Bulk Inquiry