Kinesin

Inhibitory Selectivity

Catalog No.	Inhibitor Name	Kinesin
A10486	Ispinesib	***
A10828	SB743921	****
A11170	AZ 3146	*
A11435	GSK923295	**
A14290	MPI-0479605	***
A14234	ARQ 621

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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Arry-520 (Filanesib)

Catalog No. A11050
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KSP 抑制剂

Arry-520 (Filanesib)是一种特异性KSP抑制剂,具有潜在抗肿瘤活性的KSP（驱动蛋白5或Eg5）。了解更多

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Ispinesib (SB-715992)

Catalog No. A10486
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KSP 抑制剂

Ispinesib (SB-715992)是驱动蛋白纺锤体蛋白的有效抑制剂，驱动蛋白纺锤体蛋白是双极有丝分裂纺锤体形成和有丝分裂细胞周期进程所必需的驱动蛋白。了解更多

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AZ 3146

Catalog No. A11170
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Mps1 抑制剂

AZ 3146是一种有效的选择性单极纺锤体1 (Mps1) 激酶抑制剂 (IC50 = 35 nM) 。它会干扰染色体对齐并覆盖纺锤体装配检查点，还抑制将Mad1，Mad2和着丝粒蛋白E（CENP-E）募集到动植物。了解更多

Product Citations (4)

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- Ryuzaburo Yuki, .et al. The tyrosine kinase v-Src modifies cytotoxicities of anticancer drugs targeting cell division, J Cell Mol Med, 2021, Feb;25(3):1677-1687 PMID: 33465289
- Yamagishi A, .et al. Targeting Insulin-Like Growth Factor 1 Receptor Delays M-Phase Progression and Synergizes with Aurora B Inhibition to Suppress Cell Proliferation, Int J Mol Sci, 2020, Feb 5;21(3) PMID: 32033461
- Kakihana A, .et al. Heat shock-induced mitotic arrest requires heat shock protein 105 for the activation of spindle assembly checkpoint, FASEB J, 2018, Nov 29:fj201801369R PMID: 30496702
- Suzuki M, .et al. Effect of MPS1 Inhibition on Genotoxic Stress Responses in Murine Tumour Cells, Anticancer Res, 2016, Jun;36(6):2783-92 PMID: 27272789
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SB 743921

Catalog No. A10828
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KSP 抑制剂

SB 743921是第二代KSP抑制剂，在癌症的临床前模型中是一种高效有效的治疗剂。了解更多

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Monastrol

Catalog No. A11976
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Kinesin-5(KIF11) 抑制剂

Monastrol是一种有效的，细胞可渗透的非微管蛋白相互作用的有丝分裂抑制剂。Monastrol通过与有丝分裂驱动蛋白Eg5结合来阻断有丝分裂（IC50 = 14μM），Eg5是纺锤体双极性所必需的运动蛋白。了解更多

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GSK-923295

Catalog No. A11435
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CENP-E 抑制剂

GSK-923295是有丝分裂驱动蛋白着丝粒相关蛋白E（CENP-E）的小分子抑制剂。了解更多

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CW069

Catalog No. A13735
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Microtubule Associated 抑制剂

CW069是微管运动蛋白HSET的变构和选择性抑制剂，IC50为75 uM，相对于KSP具有明显的选择性。了解更多

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ARQ 621

Catalog No. A14234
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Eg5 mitotic motor protein 抑制剂

ARQ 621是一种变构选择性Eg5有丝分裂运动蛋白抑制剂。了解更多

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MPI-0479605

Catalog No. A14290
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Mps1 抑制剂

MPI-0479605是有丝分裂激酶Mps1的ATP竞争性和选择性抑制剂。了解更多

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ARRY-520 R enantiomer

Catalog No. A15001
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KSP 抑制剂

ARRY-520 R enantiomer是ARRY-520的R形式，它是一种合成的小分子驱动蛋白纺锤体蛋白（KSP）抑制剂，IC50为6 nM。了解更多

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Dimethylenastron

Catalog No. A15841
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Kinesin Eg5 抑制剂

Dimethylenastron是有丝分裂运动驱动蛋白Eg5的抑制剂，IC50值为200 nM。了解更多

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K 858

Catalog No. A15844
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Kinesin Eg5 抑制剂

K 858是一种选择性ATP不竞争的有丝分裂驱动蛋白Eg5抑制剂，IC50值为1.3 uM。了解更多

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EMD534085

Catalog No. A15956
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Kinesin 抑制剂

EMD534085是有效选择性的有丝分裂驱动蛋白-5 (kinesin-5)的抑制剂，IC50值为8 nM。了解更多

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Litronesib Racemate

Catalog No. A21498
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kinesin Eg5 inhibitor

Litronesib (Racemate) is the racemate of litronesib. Litronesib is a selective, allosteric inhibitor of kinesin Eg5. 了解更多

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