ML-210

Name: ML-210
SKU: A20475
Price: 175 CNY
Rating: 5 (1 reviews)

目录号: A20475

GPX4 抑制剂

1 篇发表文献

ML-210，硝基异噁唑系列中最有效的化合物，是通过与硒代半胱氨酸残基结合，选择性共价抑制谷胱甘肽过氧化物酶4（GPX4）的抑制剂。

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Grouped product items
规格	价格	库存
1mg	¥175.00	现货
2mg	¥280.00	现货
5mg	¥490.00	现货
10mg	¥945.00	现货
25mg	¥1,750.00	现货
50mg	¥2,940.00	现货
100mg	¥4,340.00	现货
200mg	¥6,195.00	现货
500mg	¥9,205.00	现货
*10mM 1mL in DMSO**	¥525.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用ML-210发表的1篇文献

Ning Li, .et al. , J Ovarian Res, 2024, Feb 23;17(1):49 PMID: 38396022

生物活性

Discription

ML-210??the most potent compound in the nitroisoxazole series?? is a selective covalent inhibitor of glutathione peroxidase 4 (GPX4) by binding the selenocysteine residue.

Cell Research

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Cell Line	Type	Value	Description	References
BJ	IC50	107 nM	Cytotoxicity against human BJ cells expressing HRAS G12V mutant with alternative oncogenic constructs after 48 hrs by alamar blue assay	[PMID: 22297109]
HCT-116	IC50	> 1 μM	Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based analysis	[PMID: 35984756]
HeLa	IC50	0.253 μM	Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based analysis	[PMID: 35984756]
HT-1080	IC50	0.022 μM	Cytotoxicity against human HT-1080 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based analysis	[PMID: 35984756]
MCF7	IC50	> 20 μM	Antiproliferative activity against human MCF7 cells assessed as reduction in cell growth incubated for 48 hrs in presence of Fer-1 by CCK8 assay	[PMID: 33725632]
MCF7	IC50	0.076 μM	Antiproliferative activity against human MCF7 cells assessed as reduction in cell growth incubated for 48 hrs by CCK8 assay	[PMID: 33725632]
MDA-MB-231	IC50	0.02 μM	Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based analysis	[PMID: 35984756]
MDA-MB-468	IC50	0.066 μM	Cytotoxicity against human MDA-MB-468 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based analysis	[PMID: 35984756]
MEF	IC50	0.016 μM	Cytotoxicity against mouse MEF cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based analysis	[PMID: 35984756]
NCI-H522	IC50	0.044 μM	Cytotoxicity against human NCI-H522 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based analysis	[PMID: 35984756]

Showing 1 to 10 of 13 entries

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产品信息

目录号	A20475
分子式	C22H20Cl2N4O4
分子量	475.32
CAS号	1360705-96-9
SMILES	O=C(N1CCN(C(C2=CC=C(Cl)C=C2)C3=CC=C(Cl)C=C3)CC1)C4=NOC(C)=C4[N+]([O-])=O
其他名称	CID 49766530; CID-49766530; CID49766530; ML 210; ML210
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	14 mg/mL (29.45 mM)
	Water	Insoluble
	Ethanol	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.04 mL	105.19 mL	210.38 mL
0.5 mM	4.21 mL	21.04 mL	42.08 mL
1 mM	2.1 mL	10.52 mL	21.04 mL
5 mM	0.42 mL	2.1 mL	4.21 mL

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