ROCK

Inhibitory Selectivity

Catalog No.	Inhibitor Name	ROCK	ROCK1	ROCK2	Other
A11001	Y-27632 2HCl		*	*
A10928	Thiazovivin	*
A10381	Fasudil HCl			*	PKA,PKG,PKC
A10441	GSK429286A		***	**
A13067	RKI-1447		***	***
A12348	GSK269962		****	****	MSK1,RSK1
A15888	Ripasudil		**	**
A15239	KD025			**
A12464	AT13148		***	****	PKA,p70S6K,Akt1

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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SR 3677 dihydrochloride

Catalog No. A12674
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ROCK 抑制剂

SR 3677 dihydrochloride是一种有效的选择性Rho激酶抑制剂（ROCK-II和ROCK-I的IC50值分别为3和56 nM）。了解更多

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Hydroxyfasudil hydrochloride

Catalog No. A15119
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ROCK 抑制剂

Hydroxyfasudil hydrochloride是法舒地尔的代谢产物，是一种有效的Rho激酶抑制剂和血管舒张剂。了解更多

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Hydroxyfasudil

Catalog No. A15118
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ROCK 抑制剂

Hydroxyfasudil是法舒地尔的代谢产物，是有效的Rho激酶抑制剂和血管舒张剂。了解更多

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ROCK inhibitor

Catalog No. A15225
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ROCK 抑制剂

ROCK inhibitor是人类ROCK-1和ROCK-2同工酶的高效抑制剂，IC50值分别为0.6和1.1 nM。了解更多

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- Nina Seidelmann, .et al. Human platelet lysate as a replacement for fetal bovine serum in human corneal stromal keratocyte and fibroblast culture, J Cell Mol Med, 2021, Oct;25(20):9647-9659 PMID: 34486211
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ROCK inhibitor-1

Catalog No. A15226
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ROCK 抑制剂

N/A 了解更多

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LX7101

Catalog No. A16211
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LIMK2 抑制剂

LX7101是基于吡咯并嘧啶的局部递送的LIM域激酶2（LIMK2）抑制剂，LIM域激酶2是与眼内压调节相关的激酶。了解更多

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Ripasudil

Catalog No. A15888
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ROCK inhibitor

Ripasudil (K-115) is potent ROCK inhibitor with IC50 of 51 nM and 19 nM for ROCK1 and ROCK2, respectively, used for the treatment of glaucoma and ocular hypertension. 了解更多

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SAR407899 HCl

Catalog No. A15921
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ROCK 抑制剂

SAR407899是一种有效且选择性的Rho激酶抑制剂，具有良好的抗高血压活性。了解更多

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SLx-2119 (KD025)

Catalog No. A15239
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ROCK2 抑制剂

SLx-2119 (KD025)是ROCK2的小分子和选择性抑制剂，IC50为105 nM。在ROCK1上的选择性> 200倍（IC50 = 24 uM）。了解更多

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Glycyl-H 1152 2HCl

Catalog No. A13659
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ROCK 抑制剂

Glycyl-H 1152 2HCl是一种选择性有效的ROCK抑制剂（ROCKII，Aurora A，CAMKII，PKG，PKA和PKC的IC50值分别为0.0118、2.35、2.57、3.26，> 10和> 10 uM。）了解更多

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H-1152 dihydrochloride

Catalog No. A15102
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ROCK 抑制剂

H-1152 dihydrochloride是一种异喹啉磺酰胺衍生物，是Rho激酶的一种更特异，更强且可透过膜的抑制剂，Ki值为1.6 nM，但对其他丝氨酸/苏氨酸激酶的抑制作用较弱。了解更多

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H-1152

Catalog No. A15101
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ROCK 抑制剂

H-1152是一种异喹啉磺酰胺衍生物，是Rho激酶的一种更特异，更强且可透过膜的抑制剂，Ki值为1.6 nM，但对其他丝氨酸/苏氨酸激酶的抑制作用较差。了解更多

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chroman 1

Catalog No. A15045
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ROCK 抑制剂

Chroman 1 是一种高效且选择性的ROCK II抑制剂。了解更多

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AT13148

Catalog No. A12464
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multi-AGC kinase 抑制剂

AT13148是一种新型多AGC激酶抑制剂，具有强大的药效和抗肿瘤活性，与其他AKT抑制剂相比，具有独特的作用机理。了解更多

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Y-33075

Catalog No. A11610
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ROCK 抑制剂

Y-33075是ROCK（Rho相关的卷曲螺旋形成蛋白激酶）抑制剂。了解更多

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RKI-1447

Catalog No. A13067
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ROCK1/ROCK2 抑制剂

RKI-1447是Rho相关ROCK激酶的有效抑制剂，在乳腺癌中具有抗侵袭和抗肿瘤活性。了解更多

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HA-1077 dihydrochloride

Catalog No. A13785
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ROCK 抑制剂

HA-1077 dihydrochloride通过充当细胞内Ca2+拮抗剂来抑制血管平滑肌收缩。了解更多

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GSK429286A

Catalog No. A10441
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ROCK 抑制剂

GSK429286A是含有蛋白激酶(ROCK)的Rho相关卷曲螺旋的细胞渗透性选择性小分子抑制剂。了解更多

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T56-LIMKi

Catalog No. A12266
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LIMK2 inhibitor

T56-LIMKi is a selective inhibitor of LIMK2; inhibits the growth of Panc-1 cells with an IC50 of 35.2 μM. 了解更多

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ROCK inhibitor-2

Catalog No. A18912
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ROCK1/ROCK2 inhibitor

ROCK inhibitor-2 is a selective dual ROCK1 and ROCK2 inhibitor with IC50s of 17 nM and 2 nM, respectively. 了解更多

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R-10015

Catalog No. A18806
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LIMK inhibitor

R-10015, a broad-spectrum antiviral compound for HIV infection, acts as a potent and selective inhibitor of LIM domain kinase (LIMK) and binds to the ATP-binding pocket, with an IC50 of 38 nM for human LIMK1. 了解更多

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Y-33075 dihydrochloride

Catalog No. A11611
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ROCK inhibitor

Y-33075 dihydrochloride is a selective ROCK inhibitor with an IC50 of 3.6 nM. 了解更多

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Y-27632

Catalog No. A21448
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ROCK-I/ROCK-II inhibitor

Y-27632 is an ATP-competitive inhibitor of ROCK-I and ROCK-II, with Ki of 220 nM and 300 nM for ROCK-I and ROCK-II, respectively. 了解更多

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- Renata Santos, .et al. Generation of inflammation-responsive astrocytes from glial progenitors derived from human pluripotent stem cells, STAR Protoc, 2022, Mar 17;3(2):101261 PMID: 35313707
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Fasudil

Catalog No. A21628
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ROCK inhibitor

Fasudil (HA-1077; AT877), is a nonspecific ROCK inhibitor and also has inhibitory effect on protein kinases. 了解更多

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BMS-3

Catalog No. A20999
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LIMK inhibitor

BMS-3 is a potent LIMK inhibitor with IC50s of 5 nM and 6 nM for LIMK1 and LIMK2, respectively. 了解更多

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BDP5290

Catalog No. A16966
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ROCK and MRCK 抑制剂

BDP5290是ROCK和MRCK的有效抑制剂，对ROCK1，ROCK2，MRCKα和MRCKβ的IC50分别为5 nM，50 nM，10 nM和100 nM。了解更多

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BMS-5

Catalog No. A12839
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LIMK 抑制剂

BMS-5是一种有效的LIMK抑制剂，对LIMK1和LIMK2的IC50分别为7 nM和8 nM。了解更多

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RKI-1313

Catalog No. A10899
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ROCK 抑制剂

RKI-1313是RKI-1447的阴性对照，RKI-1447是Rho相关的ROCK激酶的有效抑制剂，在乳腺癌中具有抗侵袭和抗肿瘤活性。了解更多

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Thiazovivin

Catalog No. A10928
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ROCK 抑制剂

Thiazovivin是一种Rho相关激酶（ROCK）的选择性抑制剂。了解更多

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GSK 269962

Catalog No. A12348
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ROCK 抑制剂

GSK 269962是一种强效Rho激酶(ROCK)抑制剂(重组人ROCK1和ROCK2的IC50值分别为1.6和4 nM)。了解更多

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- Praneeth Siripurapu, .et al. Two independent but synchronized Gβγ subunit-controlled pathways are essential for trailing-edge retraction during macrophage migration, J Biol Chem, 2017, Oct 20; 292(42): 17482-17495 PMID: 28864771
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Fasudil HCl (HA-1077)

Catalog No. A10381
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ROCK 抑制剂

Fasudil HCl (HA-1077)是一种环状核苷酸依赖性蛋白激酶抑制剂和Rho相关激酶抑制剂（IC50 = 10.7μM）。了解更多

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- Chengyu Xiang, .et al. Fasudil Ameliorates Osteoporosis Following Myocardial Infarction by Regulating Cardiac Calcitonin Secretion, J Cardiovasc Transl Res, 2022, May 12 PMID: 35551627
- Yeonmi Lee, .et al. Haploidy in somatic cells is induced by mature oocytes in mice, Commun Biol, 2022, Jan 25;5(1):95 PMID: 35079104
- Jiwan Choi, .et al. Efficient hepatic differentiation and regeneration potential under xeno-free conditions using mass-producible amnion-derived mesenchymal stem cells, Stem Cell Res Ther, 2021, Nov 12;12(1):569
- Jee Myung Yang, .et al. Long-term effects of human induced pluripotent stem cell-derived retinal cell transplantation in Pde6b knockout rats, Exp Mol Med, 2021, Apr;53(4):631-642 PMID: 33828232
- Jooyoung Lee, .et al. Hepatogenic Potential and Liver Regeneration Effect of Human Liver-derived Mesenchymal-Like Stem Cells, Cells, 2020, Jun; 9(6): 1521 PMID: 32580448
- Kumar M, .et al. Fasudil hydrochloride ameliorates memory deficits in rat model of streptozotocin-induced Alzheimer's disease: Involvement of PI3-kinase, eNOS and NFκB, Behav Brain Res, 2018, Oct 1;351:4-16 PMID: 29807069
- Wei J, .et al. Inhibition of RHO Kinase by Fasudil Attenuates Ischemic Lung Injury After Cardiac Arrest in Rats, Shock, 2018, Dec;50(6):706-713 PMID: 29283979
- Hofni A, .et al. Fasudil ameliorates endothelial dysfunction in streptozotocin-induced diabetic rats: a possible role of Rho kinase, Naunyn Schmiedebergs Arch Pharmacol, 2017, Aug;390(8):801-811 PMID: 28493050
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Y-27632 2HCl

Catalog No. A11001
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ROCK 抑制剂

Y-27632是一种Rho相关的线圈激酶（ROCK）抑制剂，可提高人类胚胎干细胞（hESCs）的克隆效率。比对其他激酶包括PKC，cAMP依赖性蛋白激酶，MLCK和PAK的作用强200多倍。了解更多

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- Sergio Pedraza-Arevalo, .et al. Differentiation of beta-like cells from human induced pluripotent stem cell-derived pancreatic progenitor organoids, STAR Protoc, 2022, Aug 30;3(3):101656 PMID: 36092820
- Ji-Hyun Lee, .et al. p57Kip2 imposes the reserve stem cell state of gastric chief cells, Cell Stem Cell, 2022, May 5; 29(5): 826-839 PMID: 35523142
- Adam Pietrobon, .et al. Renal organoid modeling of tuberous sclerosis complex reveals lesion features arise from diverse developmental processes, Cell Rep, 2022, Jul 5;40(1):111048 PMID: 35793620
- Sarkawt Hamad, .et al. High-efficient serum-free differentiation of endothelial cells from human iPS cells, Stem Cell Res Ther, 2022, Jun 11;13(1):251 PMID: 35690874
- Stasia Krishtul, .et al. Development of a bioactive microencapsulation platform incorporating decellularized extracellular matrix to entrap human induced pluripotent stem cells for versatile biomedical applications, Polym Adv Technol, 2022, 33( 11): 3842-3852
- Peter T Ruane, .et al. Trophectoderm differentiation to invasive syncytiotrophoblast is promoted by endometrial epithelial cells during human embryo implantation, Hum Reprod, 2022, Apr 1;37(4):777-792 PMID: 35079788
- Takayuki Miyoshi, .et al. Successful induction of human chemically induced liver progenitors with small molecules from damaged liver, J Gastroenterol, 2022, Jun;57(6):441-452 PMID: 35294680
- Ana-Maria Cujba, .et al. An HNF1α truncation associated with maturity-onset diabetes of the young impairs pancreatic progenitor differentiation by antagonizing HNF1β function, Cell Rep, 2022, Mar 1;38(9):110425 PMID: 35235779
- Dan Zhao, .et al. From crypts to enteroids: establishment and characterization of avian intestinal organoids, Poult Sci, 2022, Mar; 101(3): 101642 PMID: 35016046
- Antigoni Gogolou, .et al. Generating Enteric Nervous System Progenitors from Human Pluripotent Stem Cells, Curr Protoc, 2021, Jun;1(6):e137 PMID: 34102038
- Tiago De Oliveira, .et al. Effects of the Novel PFKFB3 Inhibitor KAN0438757 on Colorectal Cancer Cells and Its Systemic Toxicity Evaluation In Vivo, Cancers (Basel), 2021, Mar 2;S2451-9456(21)00095-7 PMID: 33671096
- Denise Muller, .et al. Functional apoptosis profiling identifies MCL-1 and BCL-xL as prognostic markers and therapeutic targets in advanced thymomas and thymic carcinomas, BMC Med, 2021, Nov 16;19(1):300 PMID: 34781947
- Ayumi Horikawa, .et al. A simple method of hiPSCs differentiation into insulin-producing cells is improved with vitamin C and RepSox, PloS one, 2021, Jul 12;16(7):e0254373 PMID: 34252142
- Hayato Mizuta, .et al. Gilteritinib overcomes lorlatinib resistance in ALK-rearranged cancer, Nat Commun, 2021, Feb 24;12(1):1261 PMID: 33627640
- Scott Bell, .et al. Lesch-Nyhan disease causes impaired energy metabolism and reduced developmental potential in midbrain dopaminergic cells, Stem Cell Reports, 2021, Jul 13;16(7):1749-1762 PMID: 34214487
- Shenyang Li, .et al. Effect of porcine corneal stromal extract on keratocytes from SMILE-derived lenticules, J Cell Mol Med, 2020, Dec 20;25(2):1207-1220 PMID: 33342057
- Takao FUCHIGAMI, .et al. Ameloblastoma cell lines derived from different subtypes demonstrate distinct developmental patterns in a novel animal experimental model, J Appl Oral Sci, 2020, 28: e20190558 PMID: 32348439
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