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| Catalog No. | Inhibitor Name | Syk | Other |
|---|---|---|---|
| A10769 | R406 besylate | ** | Flt3 |
| A10770 | R406 (Tamatinib) | ** | Flt3 |
| A10771 | R788 Disodium | ** | |
| A12731 | PRT062607 HCl | **** | FGR,MLK1,YES |
| A11926 | Fostamatinib | ** | Adenosine A3 receptor,Adenosine transporter,Monoamine transporter |
| A16240 | MNS | * | p97,Src |
| A15524 | PRT-060318 | **** | |
| A13884 | Entospletinib | *** | |
| A11320 | BAY-61-3606 | *** | |
| A12162 | Piceatannol | Lyn,PKA,PKC | |
| A11952 | P505-15 (PRT062607, BIIB057) | **** | FGR, MLK1 |
| A14161 | R112 | * |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
20 个项目
每页
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BAY 61-3606
Catalog No. A11320 Syk 抑制剂BAY 61-3606是一种细胞可渗透的咪唑并嘧啶化合物，可作为Syk酪氨酸激酶活性的有效，ATP竞争性，可逆和高度选择性抑制剂，而对Btk，Fyn，Itk，Lyn和Src无抑制作用。 了解更多 -
R788 (Fostamatinib)
Catalog No. A11926 Syk 抑制剂R788 (Fostamatinib)是重要的脾酪氨酸激酶（Syk）抑制剂，显示出对激酶介导的IgG Fcγ受体信号转导的功效。 了解更多 -
P505-15 (PRT062607, BIIB057)
Catalog No. A11952 Syk 抑制剂P505-15 (PRT062607,BIIB057)是一种新型的，高度选择性的，Syk抑制剂（SYK IC（50）= 1 nM），具有比SYK活性至少高80倍的抗SYK活性。 了解更多 -
TAK-659 hydrochloride
Catalog No. A21885 Syk inhibitorTAK-659 hydrochloride is a potent, selective and orally available spleen tyrosine kinase (Syk) inhibitor with an IC50 of 3.2 nM. 了解更多 -
Fostamatinib disodium hexahydrate
Catalog No. A21873 Syk inhibitorFostamatinib disodium hexahydrate (R788 disodium hexahydrate), a prodrug of the active metabolite R406, is a potent Syk inhibitor with IC50 of 41 nM. 了解更多 -
Lanraplenib
Catalog No. A12959 SYK inhibitorLanraplenib (GS-9876) is a highly selective and orally active SYK inhibitor (IC50=9.5 nM) in development for the treatment of inflammatory diseases. 了解更多 -
PRT 062070 (Cerdulatinib)
Catalog No. A14147 Dual Syk and JAK 抑制剂PRT 062070 (Cerdulatinib)是一种新型的口服双脾酪氨酸激酶（Syk）和janus激酶（JAK）抑制剂。Cerdulatinib优先抑制各种细胞类型中JAK1和JAK3依赖性细胞因子介导的信号传导和功能性反应。 了解更多 -
BAY 61-3606 dihydrochloride
Catalog No. A15017 -
R112
Catalog No. A14161 -
Gusacitinib
Catalog No. A19883 SYK/JAK inhibitorGusacitinib (ASN-002) is a potent dual inhibitor of spleen tyrosine kinase (SYK) and janus kinase (JAK) with IC50 values of 5-46 nM. 了解更多 -
PRT062607 HCL
Catalog No. A12731 Syk 抑制剂PRT2607，也称为PRT062607，P505-15和BIIB057，是一种新型，高度选择性且口服可生物利用的小分子SYK抑制剂（SYK IC（50）= 1 nM），具有至少80倍的抗SYK活性 大于对其他激酶的亲和力。 了解更多 -
GS-9973 (Entospletinib)
Catalog No. A13884 -
Piceatannol
Catalog No. A12162 -
R935788 (Fostamatinib disodium, R788)
Catalog No. A10771 Syk 抑制剂R935788 (Fostamatinib disodium,R788)是一种有效的口服Syk抑制剂，可通过阻断抗原依赖性B细胞受体信号传导来抑制CLL的Eμ-TCL1转基因小鼠模型中的肿瘤生长。 了解更多 -
R406 (Tamatinib)
Catalog No. A10770 Syk 抑制剂R406 (Tamatinib)是一种口服酪氨酸激酶抑制剂，IC50为41 nM。对Syk抑制作用强，但是不抑制Lyn，对Flt3的作用比对Syk低5倍。 了解更多 -
R406 besylate
Catalog No. A10769 Syk 抑制剂R406 besylate是一种口服酪氨酸激酶抑制剂，IC50为41 nM。对Syk抑制作用强，但是不抑制Lyn，对Flt3的作用比对Syk低5倍。 了解更多
20 个项目
每页