TNF-α

Inhibitory Selectivity

Catalog No.	Inhibitor Name	TNF-α	Other
A10743	Pomalidomide	***
A11973	Necrostatin-1	*
A12748	QNZ	****	NF-κB
A10924	Thalidomide
A10522	Lenalidomide (CC-5013)	***

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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Lenalidomide (CC-5013)

Catalog No. A10522
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Ubiquitin ligase inducer

Lenalidomide (CC-5013)是Thalidomide的衍生物。在体外，Lenalidomide具有三种主要活性:直接抗肿瘤作用、抑制肿瘤细胞的微环境支持和免疫调节作用。它通过抑制骨髓基质细胞支持、抗血管生成和抗破骨细胞生成作用以及免疫调节活性直接和间接诱导肿瘤细胞凋亡。了解更多

Product Citations (4)

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- Daniel A. Rauch, .et al. Interferon regulatory factor 4 as a therapeutic target in adult T-cell leukemia lymphoma, Retrovirology, 2020, 17: 27 PMID: 32859220
- A Hayano, .et al. Cell-type-specific sensitivity of bortezomib in the methotrexate-resistant primary central nervous system lymphoma cells, Int J Clin Oncol, 2019, 1-10 PMID: 30993483
- Kumar R, .et al. Novel combination of tanshinone I and lenalidomide induces chemo-sensitivity in myeloma cells by modulating telomerase activity and expression of shelterin complex and its associated molecules, Mol Biol Rep, 2018, Oct 11 PMID: 30311125
- Hirosumi Tamura, .et al. Evaluation of anticancer agents using patient-derived tumor organoids characteristically similar to source tissues, Oncol Rep, 2018, Aug; 40(2): 635-646 PMID: 29917168
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QNZ (EVP4593)

Catalog No. A12748
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NF-κB 抑制剂

QNZ抑制转录因子NF-κB的激活，已被用于研究NF-κB信号传导。了解更多

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Pomalidomide (CC-4047)

Catalog No. A10743
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TNF-alpha 抑制剂

Pomalidomide (CC-4047)是沙利度胺的衍生物，在PBMCs中IC50为13 nM，并起免疫调节剂的作用。了解更多

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Necrostatin-1

Catalog No. A11973
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RIPK1 抑制剂

Necrostatin-1是一种与ATP竞争的，与受体相互作用的蛋白激酶1（RIPK1）的变构抑制剂（EC50 = 182 nM）。了解更多

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GW 4869

Catalog No. A11974
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N-SMase 抑制剂

W4869是N-SMase（中性鞘磷脂酶）的细胞渗透性选择性抑制剂。了解更多

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- Guohao Wang, .et al. A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis, Nat Commun, 2021, Sep 30;12(1):5733 PMID: 34593794
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Necrostatin 2

Catalog No. A15183
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Necroptosis 抑制剂

Necrostatin 2 是一种有效的坏死性抑制剂，EC50为50 nM。了解更多

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Necrostatin 2 racemate

Catalog No. A15327
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Necroptosis 抑制剂

Necrostatin 2 racemate是一种有效的坏死性抑制剂，EC50为50 nM。了解更多

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Necrostatin 2 S enantiomer

Catalog No. A15328
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Necroptosis 抑制剂

Necrostatin 2 S enantiomer是一种有效的坏死性抑制剂，EC50为50 nM。了解更多

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Thalidomide

Catalog No. A10924
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E3 ubiquitin ligase 抑制剂

Thalidomide可以在体内直接抑制bFGF或VEGF诱导的血管生成。了解更多

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C 87

Catalog No. A12313
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TNFα inhibitor

C87 is a novel small-molecule TNFα inhibitor; potently inhibits TNFα-induced cytotoxicity with an IC50 of 8.73 μM. 了解更多

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