Aromatase

Inhibitory Selectivity

Catalog No.	Inhibitor Name	Aromatase
A10523	Letrozole	****
A10075	Anastrozole	***
A10378	Exemestane	***

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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Fulvestrant (Faslodex)

Catalog No. A10410
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Aromatase 抑制剂

Fulvestrant是一种雌激素受体拮抗剂，没有激动剂作用，它通过下调和降解雌激素受体发挥作用。了解更多

Product Citations (5)

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- Samy A. F. Morad, .et al. Role of P-glycoprotein inhibitors in ceramide-based therapeutics for treatment of cancer, Biochem Pharmacol, 2017, Apr 15; 130: 21-33 PMID: 28189725
- Kaneyasu Nishimura, .et al. Estradiol Facilitates Functional Integration of iPSC-Derived Dopaminergic Neurons into Striatal Neuronal Circuits via Activation of Integrin α5β1, Stem Cell Reports, 2016, Apr 12; 6(4): 511-524 PMID: 26997644
- Alejandro S. Cazzulino, .et al. Improved specificity of hippocampal memory trace labeling, Hippocampus, 2016, Jun; 26(6): 752-762 PMID: 26662713
- Rie Mukai, .et al. 8-Prenylnaringenin promotes recovery from immobilization-induced disuse muscle atrophy through activation of the Akt phosphorylation pathway in mice, Am J Physiol Regul Integr Comp Physiol, 2016, Dec 1;311(6):R1022-R1031 PMID: 27629889
- Sakanashi M, .et al. Long-term treatment with san'o-shashin-to, a kampo medicine, markedly ameliorates cardiac ischemia-reperfusion injury in ovariectomized rats via the redox-dependent mechanism., Circ J. , 2013, 77(7):1827-37. PMID: 23615023
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Chrysin

Catalog No. A10209
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Aromatase 抑制剂

Chrysin是从蓝色西番莲（Passiflora caerulea）中化学提取的天然黄酮。已经显示出诱导抗炎作用，最可能是通过抑制COX-2表达和通过IL-6信号传导。在啮齿动物体内研究中，发现了菊花素具有抗焦虑作用。了解更多

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Alpha-Naphthoflavone

Catalog No. A18474
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aromatase inhibitor

Alpha-Naphthoflavone is a synthetic flavonoid, acts as a potent and competitive aromatase inhibitor with an IC50 and a Ki of 0.5 and 0.2 μM, respectively. 了解更多

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Fadrozole hydrochloride

Catalog No. A21258
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Aromatase inhibitor

Fadrozole hydrochloride is a potent, selective and nonsteroidal inhibitor of aromatase with an IC50 of 6.4 nM. 了解更多

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Anastrozole

Catalog No. A10075
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Aromatase 抑制剂

Anastrozole是第三代非甾体选择性芳香化酶抑制剂。与其他芳香酶抑制剂相比，它可能具有更高的选择性，没有任何内在的内分泌作用，并且对肾上腺类固醇的合成也没有明显的作用。了解更多

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Exemestane

Catalog No. A10378
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Aromatase 抑制剂

Exemestane是一种口服类固醇芳香化酶抑制剂，除绝经后妇女的手术和/或放疗外，还用于ER阳性乳腺癌。了解更多

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Letrozole

Catalog No. A10523
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Aromatase 抑制剂

Letrozole是芳香酶抑制剂。CGS 20267是一种新型的非甾体化合物，在体外（IC50为11.5 nM）和在体内（ED50为1-3μg/ kg p.o.）均能有效抑制芳香化酶。了解更多

Product Citations (1)

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- WEI LIU, .et al. Randomized controlled trial comparing letrozole with laparoscopic ovarian drilling in women with clomiphene citrate-resistant polycystic ovary syndrome, Exp Ther Med, 2015, Oct; 10(4): 1297-1302 PMID: 26622481
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Fadrozole

Catalog No. A11088
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Aromatase 抑制剂

Fadrozole是一种非甾体芳香化酶抑制剂，在体内和体内雌激素的生物合成中均表现出非常有效和选择性的抑制作用。了解更多

Product Citations (3)

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- Steve U. Ayobahan, .et al. A combined FSTRA-shotgun proteomics approach to identify molecular changes in zebrafish upon chemical exposure, Sci Rep, 2019, 9, Article number: 6599
- Muth-Köhne E, .et al. Linking the response of endocrine regulated genes to adverse effects on sex differentiation improves comprehension of aromatase inhibition in a Fish Sexual Development Test, Aquat Toxicol, 2016, Jul;176:116-27 PMID: 27130971
- Ma YN, .et al. Effects of azocyclotin on gene transcription and steroid metabolome of hypothalamic-pituitary-gonad axis, and their consequences on reproduction in zebrafish (Danio rerio), Aquat Toxicol, 2016, Oct;179:55-64 PMID: 27571716