Chk

Inhibitory Selectivity

Catalog No.	Inhibitor Name	Chk1	Chk2	Other
A10113	AZD7762	***
A11036	LY2603618	***
A11167	MK-8776	***	*	CDK2
A11046	CHIR-124	****	*	FLT3,PDGFR,GSK-3
A11520	PF-477736	****	**	VEGFR2,Fms,YES
A11108	CCT241533		****
A13575	BML-277		***
A15480	SB 218078	***		cdc2, PKC
A15550	CCT244747	**

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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R1530

Catalog No. A13111
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Chk2, KDR, FGFR, Aurora A & Cdk2 抑制剂

R1530是吡唑并苯并二氮杂小分子，具有潜在的抗血管生成和抗肿瘤活性。R1530也是一种有丝分裂-血管生成抑制剂(MAI),可抑制多种参与血管生成的受体酪氨酸激酶，如血管内皮生长因子受体(VEGFR)-1，-2，-3，血小板衍生生长因子受体(PDGFR)βFMS样酪氨酸激酶(Flt)-3和成纤维细胞生长因子受体(FGFR) -1，-2。了解更多

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