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￥ 0.00 CSF-1R
| Catalog No. | Inhibitor Name | CSF-1R | Other |
|---|---|---|---|
| A10025 | Linifanib | *** | VEGFR1/FLT1,FLT3,VEGFR2/KDR |
| A10679 | OSI-930 | ** | FLT1,KDR,LCK |
| A11959 | GW2580 | * | |
| A13772 | CEP-32496 | *** | c-Kit,RET,PDGFRβ |
| A15520 | Pexidartinib | ** | |
| A15540 | BLZ945 | **** | |
| A11472 | Ki 20227 | **** | VEGFR-2, PDGFRβ, c-Kit |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
15 个项目
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JNJ-28312141
Catalog No. A12687 CSF1R 抑制剂JNJ-28312141是一种口服活性CSF1R抑制剂（Colony-stimulating factor-1受体，CRF1R），也是一种FLT3抑制剂。CSF1R在许多肿瘤中表达，是巨噬细胞的生长因子并介导破骨细胞分化。JNJ-28312141代表一种在急性髓样白血病中以及在依赖CSF-1的巨噬细胞和破骨细胞有助于肿瘤生长和骨骼事件的环境中具有潜在治疗活性的新药物。 了解更多 -
JTE-952
Catalog No. A18391 CSF-1R 抑制剂TE-952 is a potent, oral active and selective Type II inhibitor of colony stimulating factor-1 receptor (CSF-1R or cFMS, type III receptor tyrosine kinase), with IC50 values of 13 nM and 261 nM for CSF1R and TrkA , respectively. Effective against a mouse collagen-induced model of arthritis. 了解更多 -
c-Fms-IN-8
Catalog No. A18879 CSF-1R, c-FMS Type II inhibitorc-Fms-IN-8 (compound 4a) is a colony stimulating factor-1 receptor (CSF-1R, c-FMS) Type II inhibitor, with an IC50 of 9.1 nM. 了解更多 -
Linifanib (ABT-869)
Catalog No. A10025 VEGFR/PDGFR 抑制剂Linifanib (ABT-869)是一种结构新颖的有效RTK，VEGF和PDGF抑制剂，对人内皮细胞，PDGFR-β，KDR和CSF-1R的IC50分别为0.2、2、4和7 nM。 了解更多 -
Pazopanib (GW-786034)
Catalog No. A11518 VEGFR 抑制剂Pazopanib (GW-786034)是VEGFR-1，VEGFR-2，VEGFR-3，PDGFR-a/β和c-kit的有效且选择性的多靶点酪氨酸激酶抑制剂，可阻止肿瘤生长并抑制血管生成。 了解更多 -
GW2580
Catalog No. A11959 -
Ki 20227
Catalog No. A11472 -
Pexidartinib (PLX3397)
Catalog No. A15520 CSF1/Kit/FLT3 抑制剂Pexidartinib (PLX3397)是KIT，CSF1R和FLT3的小分子酪氨酸激酶（RTK）抑制剂，具有潜在的抗肿瘤活性。 了解更多 -
Edicotinib
Catalog No. A13008 CSF-1 receptor inhibitorEdicotinib is a selective and orally available colony-stimulating factor-1 (CSF-1) receptor inhibitor, and has entered phase IIA clinical trial to study rheumatoid arthritis (RA) despite disease. 了解更多 -
GENZ-882706
Catalog No. A12484 CSF-1R InhibitorGENZ-882706 is a potent colony stimulating factor-1 receptor (CSF-1R) Inhibitor extracted from patent WO 2017015267A1. 了解更多
15 个项目
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- Inhibitor (抑制剂) (15)
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- B-Raf (1)
- C-Raf (Raf-1) (1)
- CSF1R (6)
- FGFR (1)
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- PDGFRα (1)
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- RET (1)
- VEGFR1 (FLT1) (1)
- VEGFR2 (FLK1) (1)
- VEGFR3 (FLT4) (1)
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