Dehydrogenases

Inhibitory Selectivity

Catalog No.	Inhibitor Name	Dehydrogenase
A10613	Mycophenolate Mofetil	***
A12902	AGI-5198	**
A11403	MK-8245	****
A15892	NCT-501	**
A15798	SW033291	****
A12997	Vidofludimus	*
A12903	AGI-6780	***
A11786	CPI-613
A10521	Leflunomide
A10320	Disulfiram
A10949	Trilostane
A12899	PluriSIn #1 (NSC 14613)
A10070	Ammonium Glycyrrhizinate
A11682	Gimeracil
A14795	Gossypol Acetate
A10353	Enoxolone
A10348	Emodin

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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CBR 5884

Catalog No. A16176
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PHGDH 抑制剂

CBR 5884是3-磷酸甘油酸脱氢酶（PHGDH）的抑制剂，可抑制细胞中3-磷酸甘油酸丝氨酸的合成，IC50值为33 uM。了解更多

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Fomepizole

Catalog No. A16164
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alcohol dehydrogenase 抑制剂

Fomepizole是一种醇脱氢酶抑制剂，用于治疗成年人的乙二醇和甲醇中毒。了解更多

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Trilostane

Catalog No. A10949
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Trilostane是用于治疗Cushing综合征的3β-羟基类固醇脱氢酶的抑制剂。了解更多

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AG-120

Catalog No. A15869
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Dehydrogenase 抑制剂

AG-120是1型异柠檬酸脱氢酶（IDH1）的抑制剂，具有潜在的抗肿瘤活性。了解更多

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NCT-501

Catalog No. A15892
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hALDH1 抑制剂?

NCT-501是一种有效且选择性的醛脱氢酶1A1（ALDH1A1）抑制剂，IC50为40 nM。了解更多

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Alda 1

Catalog No. A15805
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ALDH2 Activator

Alda 1是醛脱氢酶2（ALDH2）的激活剂。了解更多

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MK-8245 Trifluoroacetate

Catalog No. A15170
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Liver-targeting SCD 抑制剂?

MK-8245 Trifluoroacetate是硬脂酰辅酶A去饱和酶（SCD）的肝靶向抑制剂，对人SCD1的IC50为1 nM，对大鼠SCD1和小鼠SCD1的IC50为3 nM，具有抗糖尿病和抗血脂异常的功效。了解更多

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Monoammoniumglycyrrhizinate

Catalog No. A14599
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Monoammoniumglycyrrhizinate是甘草根的一种成分，具有重要的抗病毒活性，已显示可通过间接机制抑制11_αHSD2（11_α羟类固醇脱氢酶2型）的表达。了解更多

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- Jung-Ho Lee, .et al. Secoiridoids from Dogwood ( Cornus officinalis) Potentiate Progesterone Signaling, J Nat Prod, 2021, Sep 24;84(9):2612-2616 PMID: 34411479
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AZD4017

Catalog No. A13542
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HSD1 抑制剂

AZD4017是一种有效的，选择性的，口服可生物利用的11b-HSD1抑制剂（11b-羟基类固醇脱氢酶1型抑制剂）。了解更多

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Vidofludimus (4SC-101)

Catalog No. A12997
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DHODH 抑制剂

Vidofludimus是一种新型的口服活性强效DHODH抑制剂。对人DHODH的IC50为134 nM。了解更多

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ASP9521

Catalog No. A14412
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ASP9521是一种新型的，选择性的，可生物利用的羟类固醇脱氢酶5型抑制剂（17bHSD5，AKR1C3）。了解更多

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CGP 3466B maleate

Catalog No. A12385
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GAPDH 抑制剂

CGP 3466B maleate是口服活性甘油醛-3-磷酸脱氢酶(gapdh)抑制剂。了解更多

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Brequinar

Catalog No. A12442
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Dihydroorotate Dehydrogenase 抑制剂

Brequinar是二氢乳清酸脱氢酶的抑制剂，二氢乳清酸脱氢酶是从头进行嘧啶生物合成的酶。了解更多

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Disulfiram

Catalog No. A10320
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Disulfiram是通过抑制乙醛脱氢酶来阻止体内酒精的加工，从而在消耗酒精时引起令人不快的反应。了解更多

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- Paul Mark Medina, .et al. Revealing the anticancer potential of candidate drugs in vivo using Caenorhabditis elegans mutant strains, Transl Oncol, 2021, Jan;14(1):100940 PMID: 33221682
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Ranolazine

Catalog No. A10780
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Ranolazine是部分脂肪酸氧化抑制剂，可将ATP的生产从脂肪酸转变为氧效率更高的碳水化合物氧化。了解更多

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CPI-613 (Devimistat)

Catalog No. A11786
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Dehydrogenase 抑制剂

CPI-613是合成的α-硫辛酸硫辛酸类似物的对映异构体的外消旋混合物，具有潜在的化学预防和抗肿瘤活性。了解更多

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- Takuji Sakuratani, .et al. Downregulation of ARID1A in gastric cancer cells: a putative protective molecular mechanism against the Harakiri-mediated apoptosis pathway, Virchows Arch, 2020, Aug 13 PMID: 32789692
- Egawa Y, .et al. Therapeutic potential of CPI-613 for targeting tumorous mitochondrial energy metabolism and inhibiting autophagy in clear cell sarcoma, PLoS One, 2018, Jun 7;13(6):e0198940 PMID: 29879220
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Gimeracil

Catalog No. A11682
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Gimeracil是一种二氢脱氢酶的抑制剂，在双链断裂修复中，抑制早期同源重组。了解更多

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Leflunomide

Catalog No. A10521
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Dehydrogenase 抑制剂

Leflunomide是一种嘧啶合成抑制剂，属于DMARD类药物。来氟米特用于缓解类风湿性关节炎引起的症状，如炎症、肿胀、僵硬和关节痛。了解更多

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Gossypol

Catalog No. A10435
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dehydrogenase inhibitor

Gossypol是一种多酚醛，渗透细胞并作为几种脱氢酶的抑制剂。了解更多

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- Amy L. Farthing, .et al. Response of northern bobwhites fed single doses of gossypol, Wildlife Society Bulletin, 2018, 42(3):460-466;
- Jin Qu, .et al. Gossypol potentiates carboplatin effects against ovarian cancer, Biomed Res, 2017, 28 (8): 3355-3361
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Mycophenolate mofetil (CellCept)

Catalog No. A10613
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IMPDH 抑制剂

Mycophenolate mofetil (CellCept)是嘌呤生物合成（特别是鸟嘌呤合成）中肌苷单磷酸脱氢酶（IMPDH）的可逆抑制剂，对T细胞和B细胞的生长是必需的。了解更多

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Celastrol

Catalog No. A10192
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Celastrol是一种有效的蛋白酶抑制剂，有效且优先抑制胰凝乳蛋白酶样的纯化的20S proteasome的活性，IC50为2.5 μM。了解更多

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- R. San Gil, .et al. Neurodegenerative disease-associated protein aggregates are poor inducers 2 of the heat shock response in neuronal-like cells, bioRxiv, 2020, Jan
- Abdin AA, .et al. Modulatory effect of celastrol on Th1/Th2 cytokines profile, TLR2 and CD3+ T-lymphocyte expression in a relapsing-remitting model of multiple sclerosis in rats., Eur J Pharmacol., 2014, 742:102-12 PMID: 25218987
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MK-8245

Catalog No. A11403
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SCD 抑制剂

MK-8245是肝脏靶向的硬脂酰CoA去饱和酶（SCD）抑制剂。MK-8245可用于治疗糖尿病和血脂异常。了解更多

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- Miyayama Y, .et al. Comparative study on the replication of HCV1b genome between wild type and cell culture adaptive mutant in regard to sensitivities against anti-HCV drugs, Microbiol Immunol, 2019, Dec 19 PMID: 31854467
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Ammonium Glycyrrhizinate (AMGZ)

Catalog No. A10070
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Dehydrogenase 抑制剂

Ammonium Glycyrrhizinate是来自Licorice root的一种独特产品，具有极高的甜味。了解更多

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CAY10566

Catalog No. A16936
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SCD1 抑制剂

CAY10566是SCD1的强效和选择性抑制剂，在小鼠和人酶测定中的IC50值分别为4.5和26 nM。了解更多

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A939572

Catalog No. A13298
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SCD1 inhibitor

A939572 is a potent, and orally bioavailable stearoyl-CoA desaturase1 (SCD1) inhibitor with IC50 values of <4 nM and 37 nM for mSCD1 and hSCD1, respectively. 了解更多

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CVT-12012

Catalog No. A21447
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SCD inhibitor

CVT-12012 is a potent and orally bioavailable stearoyl-coA desaturase (SCD) inhibitor, with IC50s of 38 nM, 6.1 nM for rat microsomal and human HEPG2, respectively. 了解更多

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MF-438

Catalog No. A20963
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SCD1 inhibitor

MF-438 is a potent and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor with an EC50 of 2.3 nM for rSCD1. 了解更多

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