Sirtuins

Inhibitory Selectivity

Catalog No.	Inhibitor Name	SIRT1	SIRT2	SIRT3	Sirtuin	Other
A10377	Selisistat (EX 527)	****
A12226	Sirtinol	*	**
A15902	SirReal2		****
A14221	Splitomicin				**
A14225	AGK2		***
A12305	Tenovin-6	***		*		p53

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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Sirtinol

Catalog No. A12226
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sirtuin 抑制剂

Sirtinol是Sirtinol NAD依赖组蛋白去乙酰化酶的细胞渗透性特异性抑制剂。在无细胞分析中，它是一种特异性SIRT1和SIRT2抑制剂，IC50分别为131 μM和38 μM。了解更多

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SirReal2

Catalog No. A15902
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Selective SIRT2 抑制剂

SirReal2是一种有效的、同型选择性Sirt2抑制剂，IC50为140 nM。了解更多

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- Yang Li, .et al. SIRT2 Promotes the Migration and Invasion of Gastric Cancer through RAS/ERK/JNK/MMP-9 Pathway by Increasing PEPCK1-Related Metabolism, Neoplasia, 2018, Jul; 20(7): 745-756 PMID: 29925042
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SRT 1720

Catalog No. A15247
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SIRT1 Activator

SRT 1720是人类SIRT1（EC1.5 = 0.16μM）相对于最接近的瑟土因同系物SIRT2和SIRT3（SIRT2：EC1.5 = 37 uM；SIRT3：EC1.5> 300 uM）的选择性激活剂。了解更多

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AK-1

Catalog No. A14370
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SIRT2 抑制剂

AK-1比SIRT1和SIRT3选择性抑制SIRT2。了解更多

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AGK2

Catalog No. A14225
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SIRT2 抑制剂

AGK2是一种有效的选择性SIRT2抑制剂，IC50为3.5μM。了解更多

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SRT2104 (GSK2245840)

Catalog No. A14188
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SIRT1 activator

SRT2104 (GSK2245840)是一种选择性sirt1激活剂，参与能量稳态的调节。了解更多

Product Citations (2)

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- Eleni Pitsillou, .et al. Interaction of small molecules with the SARS-CoV-2 main protease in silico and in vitro validation of potential lead compounds using an enzyme-linked immunosorbent assay, Comput Biol Chem, 2020, 89: 107408 PMID: 33137690
- Liu X, .et al. Exploring the role of orexin B-sirtuin 1-HIF-1α in diabetes-mellitus induced vascular endothelial dysfunction and associated myocardial injury in rats, Life Sci, 2019, Nov 9:117041 PMID: 31715188
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Inauhzin

Catalog No. A12527
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SIRT1 抑制剂

Inauhzin是一种有效的SirT1/IMPDH2 的双重抑制剂，可通过抑制SIRT1活性有效地重新激活p53，促进人类癌细胞的p53依赖性凋亡，而不会引起明显的遗传毒性应激。了解更多

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Tenovin-6

Catalog No. A12305
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p53 activator

Tenovin-6是tenovin-1的类似物。Tenovin-6在体外抑制纯化的人SIRT1、SIRT2和SIRT3的蛋白脱乙酰酶活性，IC50值分别为21、10和67 uM。了解更多

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- Igase M,, .et al. Tenovin-6 induces the SIRT-independent cell growth suppression and blocks autophagy flux in canine hemangiosarcoma cell lines, Exp Cell Res, 2019, Dec 28:111810 PMID: 31891684
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AK-7

Catalog No. A12904
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SIRT2 抑制剂

AK-7是SIRT2的细胞和脑渗透抑制剂（IC50 = 15.5 μM）。了解更多

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EX 527 (Selisistat)

Catalog No. A10377
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SIRT1 抑制剂

EX 527 (Selisistat)是一种有效的选择性SIRT1 III类组蛋白脱乙酰基酶抑制剂，在无细胞分析中的IC50为38 nM。了解更多

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- Takeshi Nakamura, .et al. Effects of NAD+ Synthesis Levels on Sirtuin 1 Deacetylase Activity in Mammalian Cells, Shimane Journal of Medical Science, 2022, 38 (2), 59-66
- Bugga Paramesha, .et al. Sirt1 and Sirt3 Activation Improved Cardiac Function of Diabetic Rats via Modulation of Mitochondrial Function, Antioxidants (Basel), 2021, Feb 24;10(3):338 PMID: 33668369
- Wenhui Yao, .et al. Icariin ameliorates endothelial dysfunction in type 1 diabetic rats by suppressing ER stress via the PPARα/Sirt1/AMPKα pathway, J Cell Physiol, 2020, 07 August
- Guang Bai, .et al. Chapter 1 - Epigenetic Tools in Chronic Pain Studies, Epigenetics of Chronic Pain, 2019, Pages 1-48
- Yoshikawa A, .et al. Deletion of Atf6α impairs astroglial activation and enhances neuronal death following brain ischemia in mice, J Neurochem, 2015, Feb;132(3):342-53 PMID: 25351847
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SRT1720 HCl

Catalog No. A10862
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SIRT1 Activator

SRT1720 HCl是一种抑制剂，旨在作为瑟土因亚型SIRT1的小分子活化剂。了解更多

Product Citations (7)

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- Eleni Pitsillou, .et al. Interaction of small molecules with the SARS-CoV-2 main protease in silico and in vitro validation of potential lead compounds using an enzyme-linked immunosorbent assay, Comput Biol Chem, 2020, 89: 107408 PMID: 33137690
- Jie Ren, .et al. Melatonin prevents chronic intermittent hypoxia-induced injury by inducing sirtuin 1-mediated autophagy in steatotic liver of mice, Sleep Breath, 2018, Nov 8 PMID: 30411173
- Rowlands BD, .et al. Acetate metabolism does not reflect astrocytic activity, contributes directly to GABA synthesis, and is increased by silent information regulator 1 activation, J Neurochem, 2017, Mar;140(6):903-918 PMID: 27925207
- Adam Khader, .et al. SRT1720, a sirtuin 1 activator, attenuates organ injury and inflammation in sepsis, J Surg Res, 2017, Nov;219:288-295 PMID: 29078895
- Adam Khader, .et al. Sirtuin 1 Stimulation Attenuates Ischemic Liver Injury and Enhances Mitochondrial Recovery and Autophagy, Crit Care Med, 2016, Aug; 44(8): e651-e663 PMID: 26963320
- Benjamin D. Rowlands, .et al. Silent information regulator 1 modulator resveratrol increases brain lactate production and inhibits mitochondrial metabolism, whereas SRT1720 increases oxidative metabolism., J Neurosci Res., 2015, Jul;93(7):1147-56 PMID: 25677687
- Khader A, .et al. Sirtuin 1 activation stimulates mitochondrial biogenesis and attenuates renal injury after ischemia-reperfusion., Transplantation, 2014, 98(2):148-56 PMID: 24918615
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SirReal1-O-propargyl

Catalog No. A20091
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Sirt2 inhibitor

SirReal1-O-propargyl is a selective and highly potent Sirtuin 2 (Sirt2) inhibitor, with an IC50 of 2.4 μM. 了解更多

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SIRT5 inhibitor 1

Catalog No. A19841
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SIRT5 inhibitor

SIRT5 inhibitor 1 is a potent Human Sirtuin 5 deacylase inhibitor, with an IC50 of 0.11 μM. 了解更多

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JFD00244

Catalog No. A19517
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SIRT2 inhibitor

JFD00244 is a sirtuin 2 (SIRT2) inhibitor. Anti-tumor effect. 了解更多

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Sirt2-IN-1

Catalog No. A19348
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Sirt2 inhibitor

Sirt2-IN-1 (Compound 9) is a sirtuin 2 (Sirt2) inhibitor with an IC50 of 163 nM. 了解更多

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SIRT-IN-1

Catalog No. A20962
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SIRT1/2/3 inhibitor

SIRT-IN-1 is a potent inhibitor of SIRT1/2/3, with IC50s of 15, 10, 33 μM, respectively. 了解更多

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SIRT-IN-2

Catalog No. A20961
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SIRT1/2/3 inhibitor

SIRT-IN-2 is a potent inhibitor of SIRT1/2/3, with IC50s of 4, 4, 7 μM, respectively. 了解更多

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SRT 1720 Hydrochloride

Catalog No. A21143
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SIRT1 activator of

SRT 1720 Hydrochloride is a selective activator of SIRT1 with an EC50 of 0.10 μM, and shows less potent activities on SIRT2 and SIRT3. 了解更多

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PROTAC Sirt2 Degrader-1

Catalog No. A20005
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Sirt2 degrader

PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide cereblon ligand for E3 ubiquitin ligase. 了解更多

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Salermide

Catalog No. A12263
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Sirt1/Sirt2 inhibitor

Salermide is an inhibitor of Sirt1 and Sirt2; can cause strong cancer-specific apoptotic cell death. 了解更多

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Cambinol

Catalog No. A12381
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SIRT1 and SIRT2 inhibitor

Cambinol is a SIRT1 and SIRT2 inhibitor with IC50 values of 56 and 59 μM, respectively. 了解更多

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SRT 2183

Catalog No. A12150
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Sirtuin-1 (SIRT1) activator

SRT 2183 is a selective Sirtuin-1 (SIRT1) activator with an EC1.5 value of 0.36 μM. SRT 2183 induces growth arrest and apoptosis, concomitant with deacetylation of STAT3 and NF-κB, and reduction of c-Myc protein levels. 了解更多

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UBCS039

Catalog No. A18961
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SIRT6 activator

UBCS039 is the first synthetic, specific Sirtuin 6 (SIRT6) activator, inducing autophagy in human tumor cells, with an EC50 of 38 μM. 了解更多

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SRT 1460

Catalog No. A19026
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SIRT1 activator

SRT 1460, a potent Sirtuin-1 (SIRT1) activator with an EC1.5 value of 2.9 μM, shows good selectivity for activation of SIRT1 versus SIRT2 and SIRT3 (EC1.5>300 μM), and is more potent than Resveratrol and the closest sirtuin homologues. 了解更多

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CAY10602

Catalog No. A19395
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SIRT1 activator

CAY10602 is a SIRT1 activator. 了解更多

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- 最新产品
MDL-800

Catalog No. A17228
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SIRT6 allosteric activator

MDL-800 is a first-in-class cellularly active SIRT6 allosteric activator. 了解更多

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3-TYP

Catalog No. A17144
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SIRT3 抑制剂

3-TYP是SIRT3抑制剂。了解更多

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Thiomyristoyl

Catalog No. A17166
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SIRT2 抑制剂

Thiomyristoyl是一种有效的特异性SIRT2抑制剂，IC50为28 nM。了解更多

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OSS-128167

Catalog No. A17048
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SIRT 6 抑制剂

OSS-128167，也称为SIRT6-IN-1，是一种有效的选择性SIRT 6抑制剂，IC50值为89 μM。了解更多

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Fisetin (Fustel)

Catalog No. A10388
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Fisetin (Fustel)是有效的Sirtuin活化化合物(STAC)，可以调节Sirtuin。了解更多

Product Citations (3)

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- Bih-Cheng Chen, .et al. Protective effect of Fisetin against angiotensin II-induced apoptosis by activation of IGF-IR-PI3K-Akt signaling in H9c2 cells and spontaneous hypertension rats, Phytomedicine, 2019, Apr; 57:1-8
- Jeng LB, .et al. Fisetin mediated apoptotic cell death in parental and Oxaliplatin/irinotecan resistant colorectal cancer cells in vitro and in vivo, J Cell Physiol, 2018, Sep;233(9):7134-7142 PMID: 29574877
- Kuan-Ho Lin, .et al. Bioactive flavone fisetin attenuates hypertension associated cardiac hypertrophy in H9c2 cells and in spontaneously hypertension rats, Journal of Functional Foods, 2018, 52: 212-218