Sirtuins

Inhibitory Selectivity

Catalog No.	Inhibitor Name	SIRT1	SIRT2	SIRT3	Sirtuin	Other
A10377	Selisistat (EX 527)	****
A12226	Sirtinol	*	**
A15902	SirReal2		****
A14221	Splitomicin				**
A14225	AGK2		***
A12305	Tenovin-6	***		*		p53

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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Fisetin (Fustel)

Catalog No. A10388
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Fisetin (Fustel)是有效的Sirtuin活化化合物(STAC)，可以调节Sirtuin。了解更多

Product Citations (3)

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- Bih-Cheng Chen, .et al. Protective effect of Fisetin against angiotensin II-induced apoptosis by activation of IGF-IR-PI3K-Akt signaling in H9c2 cells and spontaneous hypertension rats, Phytomedicine, 2019, Apr; 57:1-8
- Jeng LB, .et al. Fisetin mediated apoptotic cell death in parental and Oxaliplatin/irinotecan resistant colorectal cancer cells in vitro and in vivo, J Cell Physiol, 2018, Sep;233(9):7134-7142 PMID: 29574877
- Kuan-Ho Lin, .et al. Bioactive flavone fisetin attenuates hypertension associated cardiac hypertrophy in H9c2 cells and in spontaneously hypertension rats, Journal of Functional Foods, 2018, 52: 212-218