Sirtuins

Inhibitory Selectivity

Catalog No.	Inhibitor Name	SIRT1	SIRT2	SIRT3	Sirtuin	Other
A10377	Selisistat (EX 527)	****
A12226	Sirtinol	*	**
A15902	SirReal2		****
A14221	Splitomicin				**
A14225	AGK2		***
A12305	Tenovin-6	***		*		p53

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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SirReal2

Catalog No. A15902
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Selective SIRT2 抑制剂

SirReal2是一种有效的、同型选择性Sirt2抑制剂，IC50为140 nM。了解更多

Product Citations (1)

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- Yang Li, .et al. SIRT2 Promotes the Migration and Invasion of Gastric Cancer through RAS/ERK/JNK/MMP-9 Pathway by Increasing PEPCK1-Related Metabolism, Neoplasia, 2018, Jul; 20(7): 745-756 PMID: 29925042
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AGK2

Catalog No. A14225
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SIRT2 抑制剂

AGK2是一种有效的选择性SIRT2抑制剂，IC50为3.5μM。了解更多

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Sirtinol

Catalog No. A12226
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sirtuin 抑制剂

Sirtinol是Sirtinol NAD依赖组蛋白去乙酰化酶的细胞渗透性特异性抑制剂。在无细胞分析中，它是一种特异性SIRT1和SIRT2抑制剂，IC50分别为131 μM和38 μM。了解更多

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AK-1

Catalog No. A14370
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SIRT2 抑制剂

AK-1比SIRT1和SIRT3选择性抑制SIRT2。了解更多

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AK-7

Catalog No. A12904
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SIRT2 抑制剂

AK-7是SIRT2的细胞和脑渗透抑制剂（IC50 = 15.5 μM）。了解更多

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