HIF

Inhibitory Selectivity

Catalog No.	Inhibitor Name	HIF	HIF1	Other
A15530	FG-2216	****	****
A15359	KC7F2	**	**
A11237	Roxadustat
A10012	2-Methoxyestradiol			Microtubule Associated
A14319	PX-478 2HCl
A12978	BAY 87-2243

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Quick View
KC7F2

Catalog No. A15359
Quick View

添加到收藏
HIF 抑制剂

KC7F2是HIF-1α蛋白翻译的抑制剂，但不是转录的抑制剂，可抑制蛋白质合成的两个关键调节子，即真核翻译起始因子4E结合蛋白1（4EBP1）和p70 S6激酶（S6K）的磷酸化。了解更多

Bulk Inquiry
Quick View
Chetomin

Catalog No. A15358
Quick View

添加到收藏
HIF 抑制剂

Chetomin是Chaetomium spp的抗生素代谢产物。它对革兰氏阳性细菌具有抑菌作用。了解更多

Bulk Inquiry
Quick View
SYP-5

Catalog No. A13031
Quick View

添加到收藏
HIF-1 inhibitor

SYP-5 is a novel HIF-1 inhibitor, suppresses tumor cells invasion and angiogenesis. 了解更多

Bulk Inquiry
Quick View
MK-8617

Catalog No. A12618
Quick View

添加到收藏
pan HIF PHD1-3 inhibitor

MK-8617 is an orally active pan-inhibitor of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) with an IC50 of 1 nM for PHD2. 了解更多

Bulk Inquiry
Quick View
ZINC13466751

Catalog No. A12522
Quick View

添加到收藏
HIF-1α/von Hippel-Lindau interaction inhibitor

ZINC13466751 is a potent inhibitor of HIF-1α/von Hippel-Lindau interaction with an IC50 of 2.0 ?M. 了解更多

Bulk Inquiry
Quick View
EL-102

Catalog No. A20925
Quick View

添加到收藏
HIF1α inhibitor

EL102 is a inhibitor of HIF1α , Which can inhibit tubulin polymerisation and decreased microtubule stability. 了解更多

Bulk Inquiry
Quick View
DMOG

Catalog No. A13998
Quick View

添加到收藏
HIF-PH 抑制剂

DMOG是HIF-PH的细胞渗透性竞争性抑制剂。它可在正常的氧气张力下（0.1至1 mM的浓度）稳定HIF-1α表达。了解更多

Product Citations (1)

Bulk Inquiry Free Sample
- Hideaki Nakamura, .et al. Differentiated embryo chondrocyte plays a crucial role in DNA damage response via transcriptional regulation under hypoxic conditions, PLoS One, 2018, 13(2): e0192136 PMID: 29466367
Quick View
(Rac)-PT2399

Catalog No. A21376
Quick View

添加到收藏
HIF-2α inhibitor

(Rac)-PT2399 (Compound 10e), the racemate of PT2399, acts as a potent and specific hypoxia-inducible factor 2a (HIF-2α) inhibitor with an IC50 of 0.01 μM. 了解更多

Bulk Inquiry
Quick View
PT-2385

Catalog No. A21561
Quick View

添加到收藏
HIF-2α inhibitor

PT-2385 is a selective HIF-2α inhibitor with a Ki of less than 50 nM. 了解更多

Bulk Inquiry
Quick View
IOX 2

Catalog No. A11924
Quick View

添加到收藏
HIF-PHD 抑制剂

IOX2是一种有效的HIF-1α脯氨酰羟化酶2（PHD2）抑制剂，在无细胞分析中的IC50为21 nM，选择性是JMJD2A，JMJD2C，JMJD2E，JMJD3或2OG加氧酶FIH的100倍以上。了解更多

Product Citations (1)

Bulk Inquiry Free Sample
- Mun Chiang Chan, etc. Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain. PLoS One. 2015; 10(7): e0132004.
Quick View
FG-4592 (Roxadustat)

Catalog No. A11237
Quick View

添加到收藏
HIF-PHs 抑制剂

FG-4592 (Roxadustat)是一种用于CKD贫血的新型缺氧诱导因子脯氨酰羟化酶抑制剂。了解更多

Product Citations (4)

Bulk Inquiry Free Sample
- Singh C, .et al. Serine and 1-carbon metabolism are required for HIF-mediated protection against retinopathy of prematurity, JCI Insight, 2019, Jul 25;4(14) PMID: 31341109
- Hideaki Nakamura, .et al. Differentiated embryo chondrocyte plays a crucial role in DNA damage response via transcriptional regulation under hypoxic conditions, PLoS One, 2018, 13(2): e0192136 PMID: 29466367
- Singh C, .et al. 3-Hydroxypyruvate Destabilizes Hypoxia Inducible Factor and Induces Angiostasis, Invest Ophthalmol Vis Sci, 2018, Jul 2;59(8):3440-3448 PMID: 30025089
- George Hoppe, .et al. Comparative systems pharmacology of HIF stabilization in the prevention of retinopathy of prematurity, Proc Natl Acad Sci U S A, 2016, May 3; 113(18): E2516–E2525 PMID: 27091985
Quick View
AFP464

Catalog No. A20978
Quick View

添加到收藏
HIF-1?? inhibitor

AFP464, is an active HIF-1α inhibitor with an IC50 of 0.25 μM, also is a potent aryl hydrocarbon receptor (AhR) activator. 了解更多

Bulk Inquiry
Quick View
PT2977

Catalog No. A18465
添加到收藏
HIF-2alpha inhibitor

PT2977 is HIF-2alpha inhibitor with an IC50 of 9 nM. 了解更多

Bulk Inquiry
Quick View
Desidustat

Catalog No. A16921
Quick View

添加到收藏
HIF hydroxylase 抑制剂

Desidustat是抗贫血药物的候选药物。它是从专利WO 2014102818 A1，化合物实施例2中提取的HIF羟化酶的抑制剂。了解更多

Bulk Inquiry
Quick View
IDF-11774

Catalog No. A16845
Quick View

添加到收藏
HIF-1 抑制剂

IDF 11774是一种低氧诱导因子-1（HIF-1）抑制剂。它降低了HIFα-1的HRE荧光素酶活性；（IC50＝3.65 μM），并阻断HIF116结肠癌细胞缺氧下的HIFα-1的积累。了解更多

Bulk Inquiry
Quick View
Vadadustat

Catalog No. A16794
Quick View

添加到收藏
HIF prolyl-hydroxylase 抑制剂

Vadadustat，也称为AKB-6548和PG-1016548，是一种有效的缺氧诱导因子脯氨酸双加氧酶抑制剂。了解更多

Bulk Inquiry
Quick View
LW6 (CAY10585)

Catalog No. A12882
Quick View

添加到收藏
HIF-1 抑制剂

LW6是新型HIF-1抑制剂，IC50为4.4 uM。了解更多

Bulk Inquiry
Quick View
HIF-2a Translation Inhibitor

Catalog No. A16181
Quick View

添加到收藏
HIF-2a translation 抑制剂

HIF-2a Translation Inhibitor（IC50值为5 uM）；独立于HIF-2a mRNA表达或HIF-2a蛋白稳定性，并独立于mTOR活性，降低常氧和低氧状态下HIF-2a蛋白和HIF-2a目标基因的表达。此外，翻译抑制剂76增强了IRP1与HIF-2a IRE（铁反应元件）的结合。了解更多

Bulk Inquiry
Quick View
GSK1278863 (Daprodustat)

Catalog No. A12671
Quick View

添加到收藏
HIF-prolyl hydroxylase 抑制剂

GSK1278863是新型的HIF-脯氨酰羟化酶抑制剂。了解更多

Bulk Inquiry Free Sample
Quick View
JNJ-42041935

Catalog No. A15793
Quick View

添加到收藏
HIF-PHD 抑制剂 II

JNJ-42041935是有效的(pKi = 7.3-7.9)，2-氧戊二酸竞争性，可逆和选择性PHD酶抑制剂。了解更多

Bulk Inquiry
Quick View
FG-2216

Catalog No. A15530
Quick View

添加到收藏
HIF-prolyl hydroxylase 抑制剂

FG-2216是一种有效的HIF-脯氨酰羟化酶抑制剂，对PDH2酶的IC50为3.9 uM；生物利用度并在体内诱导显着且可逆的Epo诱导。了解更多

Bulk Inquiry Free Sample
Quick View
Echinomycin

Catalog No. A14021
Quick View

添加到收藏
HIF-1α 抑制剂

Hypoxia-inducible factor-1 (HIF-1)是一种转录因子，可控制参与糖酵解，血管生成，迁移和侵袭的基因。棘霉素是HIF-1介导的基因转录的细胞可渗透抑制剂了解更多

Bulk Inquiry
Quick View
Molidustat

Catalog No. A14404
Quick View

添加到收藏
HIF-PH 抑制剂

Molidustat是一种新型的低氧诱导因子（HIF）脯氨酰羟化酶（PH）抑制剂，可刺激促红细胞生成素（EPO）的产生和红细胞的形成。了解更多

Bulk Inquiry Free Sample
Quick View
PX-478 HCl

Catalog No. A14319
Quick View

添加到收藏
HIF-1alpha 抑制剂

PX-478 HCl是HIF-1alpha抑制剂，也是具有潜在抗肿瘤活性小分子。PX-478对已建立的人类肿瘤异种移植物具有出色的活性，可提供具有HIF-1水平正相关的延长的生长延迟的肿瘤消退。PX-478是高度水溶性的分子，具有良好的i.v.，i.p.和p.o.抗肿瘤活性。了解更多

Bulk Inquiry Free Sample
Quick View
BAY 87-2243

Catalog No. A12978
Quick View

添加到收藏
HIF 抑制剂

BAY 87-2243是低氧诱导基因激活的高效选择性抑制剂，通过抑制线粒体复合体I具有抗肿瘤活性。了解更多

Bulk Inquiry Free Sample
Quick View
HIF-C2

Catalog No. A12921
Quick View

添加到收藏
HIF-2 抑制剂

HIF-C2是一种有效的选择性缺氧诱导因子2（HIF-2）变构抑制剂。了解更多

Bulk Inquiry
Quick View
FM19G11

Catalog No. A12883
Quick View

添加到收藏
HIFα 抑制剂

FM19G11是缺氧诱导因子α（HIFα）的抑制剂，缺氧诱导因子α（HIFα）是一种转录因子，可对细胞环境中可用氧的变化做出响应。了解更多

Bulk Inquiry