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￥ 0.00 HIV Integrase
HIV Integrase is an enzyme found in HIV (and other retroviruses). HIV uses integrase to insert (integrate) its viral DNA into the DNA of the host CD4 cell. Integration is a crucial step in the HIV life cycle and is blocked by a class of antiretroviral (ARV) HIV drugs called integrase strand transfer inhibitors (INSTIs).
| Catalog No. | Inhibitor Name | Integrase |
|---|---|---|
| A10775 | Raltegravir (MK-0518) | * |
| A10347 | Elvitegravir (GS-9137, JTK-303) | **** |
| A11068 | Dolutegravir (GSK1349572) | *** |
| A10156 | BMS-707035 | ** |
| A11135 | MK-2048 | *** |
| A16014 | Cabotegravir (GSK744, GSK1265744) |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
13 个项目
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Raltegravir (MK-0518)
Catalog No. A10775 HIV-1 integrase 抑制剂Raltegravir (MK-0518)靶向整合酶，这是一种HIV酶，可将病毒遗传物质整合到人类染色体中，这是HIV发病机理中的关键步骤。 了解更多 -
S/GSK1349572 (Dolutegravir)
Catalog No. A11068 HIV integrase 抑制剂S/GSK1349572是有效的下一代HIV整合酶抑制剂，并通过60个整合酶突变分子克隆证实了优异的耐药性。 了解更多 -
BMS-707035
Catalog No. A10156 HIV-1 integrase 抑制剂BMS-707035是HIV-1整合酶（IN）抑制剂。HIV-1整合酶（IN）代表临床上治疗HIV/AIDS的具有治疗优势的病毒靶标。 了解更多 -
Elvitegravir (GS-9137)
Catalog No. A10347 HIV integrase 抑制剂Elvitegravir (GS-9137)是一种有效的抑制剂，可抑制人类1型免疫缺陷病毒（HIV-1）整合酶介导的整合链转移步骤。 了解更多 -
GSK1265744 (GSK744) Sodium salt
Catalog No. A13984 -
GSK744 (S/GSK1265744)
Catalog No. A16014 HIV integrase 抑制剂GSK744 (S/GSK1265744)是一种有效的HIV整合酶抑制剂，可作为口服导入片剂和长效注射剂，用于治疗和预防HIV感染。 了解更多 -
Dolutegravir Sodium
Catalog No. A16162 HIV integrase 抑制剂Dolutegravir Sodium是一种HIV整合酶抑制剂（IC50 = 2.7 nM），对耐raltegravir的签名突变体Y143R，Q148K，N155H和G140S/Q148H具有中等活性。 了解更多 -
Bictegravir
Catalog No. A17011 HIV-1 integrase 抑制剂Bictegravir，也称为GS-9883，是一种有效的，未经增强的，每日一次的HIV-1整合酶链转移抑制剂（INSTI）（IC50-1.6 nM），具有改善的药代动力学和体外耐药性。 了解更多 -
Raltegravir potassium
Catalog No. A21403 integrase (IN) inhibitorRaltegravir is a potent integrase (IN) inhibitor, used to treat HIV infection. 了解更多 -
HIV-1 integrase inhibitor
Catalog No. A11446 -
HIV-1 integrase inhibitor 2
Catalog No. A11447 HIV-1 integrase inhibitorHIV-1 integrase inhibitor 2, in the treatment of human immunodeficiency virus (HIV) infection. 了解更多
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