MDM2

Inhibitory Selectivity

Catalog No.	Inhibitor Name	Mdm2	Other
A10657	Nutlin-3	**
A11501	Nutlin-3a	***
A11502	Nutlin-3b	*
A16348	MX69	**
A15440	MI-773 (SAR405838)	****	p53
A14211	Idasanutlin (RG-7388)	****
A11523	RG-7112	***
A14118	YH239-EE

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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MD-224

Catalog No. A18712
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MDM2 degrader

MD-224 is a first-in-class and highly potent small-molecule human murine double minute 2 (MDM2) degrader based on the proteolysistargeting chimera (PROTAC) concept. MD-224 has the potential to be a new class of anticancer agent. 了解更多

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PROTAC MDM2 Degrader-1

Catalog No. A18897
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MDM2 degrader

PROTAC MDM2 Degrader-1 is a MDM2 degrader based on PROTAC technology. PROTAC MDM2 Degrader-1 composes of a potent MDM2 inhibitor, linker, and the MDM2 ligand for E3 ubiquitin ligase. 了解更多

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PROTAC MDM2 Degrader-3

Catalog No. A18883
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MDM2 degrader

PROTAC MDM2 Degrader-3 is a MDM2 degrader based on PROTAC technology. PROTAC MDM2 Degrader-3 composes of a potent MDM2 inhibitor, linker, and the MDM2 ligand for E3 ubiquitin ligase. 了解更多

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