MDM2

Inhibitory Selectivity

Catalog No.	Inhibitor Name	Mdm2	Other
A10657	Nutlin-3	**
A11501	Nutlin-3a	***
A11502	Nutlin-3b	*
A16348	MX69	**
A15440	MI-773 (SAR405838)	****	p53
A14211	Idasanutlin (RG-7388)	****
A11523	RG-7112	***
A14118	YH239-EE

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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NSC-207895 (XI-006)

Catalog No. A11179
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MDMX 抑制剂

NSC-207895 (XI-006)是细胞可渗透的苯并呋喃化合物，可通过抑制MDMX启动子转录活性（IC50 = 2.5 ?M，下调MCF-7，LNCaP和A549细胞中的p53负调节剂MDMX蛋白水平（1至10 ?M，持续16至24 h）），导致增强的p53稳定和激活。了解更多

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SJ 172550

Catalog No. A15352
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MDMX 抑制剂

SJ 172550是第一种MD50抑制剂，EC50为0.84 uM；与MDMX可逆结合，并有效杀死其中放大了MDMX表达的成视网膜细胞瘤细胞。了解更多

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WK23

Catalog No. A14051
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MDM2/MDMX 抑制剂

WK23是基于四个芳香族基团的抑制剂，能够有效填充MDM2/MDMX的结合口袋，其对MDM2/MDMX的中位抑制浓度（IC50）值分别为1.17和36 uM。了解更多

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