MDM2

Inhibitory Selectivity

Catalog No.	Inhibitor Name	Mdm2	Other
A10657	Nutlin-3	**
A11501	Nutlin-3a	***
A11502	Nutlin-3b	*
A16348	MX69	**
A15440	MI-773 (SAR405838)	****	p53
A14211	Idasanutlin (RG-7388)	****
A11523	RG-7112	***
A14118	YH239-EE

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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p53 and MDM2 proteins-interaction-inhibitor racemic

Catalog No. A15202
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p53-MDM2 interaction 抑制剂

p53和MDM2蛋白相互作用抑制剂消旋体是p53和MDM2蛋白之间相互作用的抑制剂。了解更多

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Nutlin 3a

Catalog No. A11501
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MDM2 抑制剂

Nutlin 3a是与p53结合的MDM2(小鼠双分钟2)有效抑制剂，可诱导p53调控基因的表达，并在表达功能性p53的细胞中表现出有效的抗增殖活性。了解更多

Product Citations (3)

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- Sho Watanabe, .et al. Schlafen 11 is a novel target for mucosal regeneration in Ulcerative Colitis, J Crohns Colitis, 2021, Feb 17 PMID: 33596306
- Shun Zhang, .et al. Sensitization of Gastric Cancer Cells to Irinotecan by p53 Activation, BPB Reports, 2019, 2, 130-133
- Momoko Ishimine, .et al. The Relationship between TP53 Gene Status and Carboxylesterase 2 Expression in Human Colorectal Cancer, Dis Markers, 2018, 2018: 5280736 PMID: 29651325
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AMG232

Catalog No. A14394
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MDM2 抑制剂

AMG 232是MDM2-p53相互作用的高效，选择性生物利用的哌啶酮抑制剂（SPR KD = 0.045 nM，SJSA-1 EdU IC50 = 9.1 nM）。了解更多

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Nutlin-3

Catalog No. A10657
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Mdm2 拮抗剂

Nutlin-3是一种有效的，选择性Mdm2(它自身和p53的环指依赖性泛素蛋白连接酶)拮抗剂，是有效的凋亡诱导剂。了解更多

Product Citations (4)

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- Maxime Parisotto, .et al. PTEN deletion in luminal cells of mature prostate induces replication stress and senescence in vivo, J Exp Med, 2018, Jun 4; 215(6): 1749-1763 PMID: 29743291
- Ohmuro-Matsuyama Y, .et al. Evaluation of protein-ligand interactions using the luminescent interaction assay FlimPIA with streptavidin-biotin linkage, Anal Biochem, 2018, Dec 15;563:61-66 PMID: 30316750
- Alisa A. Garaeva, .et al. Mitochondrial dysfunction induces SESN2 gene expression through Activating Transcription Factor 4, Cell Cycle, 2016, 15(1): 64-71 PMID: 26771712
- A G Evstafieva, .et al. A sustained deficiency of mitochondrial respiratory complex III induces an apoptotic cell death through the p53-mediated inhibition of pro-survival activities of the activating transcription factor 4, Cell Death Dis., 2014, 5(11): e1511. PMID: 25375376
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Idasanutlin (RG7388)

Catalog No. A14211
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MDM2/p53 抑制剂

Idasanutlin (RG7388)是一种有效的选择性p53-MDM2抑制剂。了解更多

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WR 1065

Catalog No. A15353
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P53/p21waf-1/MDM2 activator

WR 1065是一种氨磷汀（Ethyol）的去磷酸化代谢产物，可防止受到辐射的直接和延迟影响。了解更多

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Nutlin 3b

Catalog No. A11502
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MDM2 抑制剂

Nutlin 3b是p53/MDM2拮抗剂或抑制剂，IC50值为13.6 uM，与相反的（-）-对映体Nutlin-3a相比，Nutlin-3的有效（+）-对映体少150倍。了解更多

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p53 and MDM2 proteins-interaction-inhibitor chiral

Catalog No. A15201
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p53-MDM2 interaction 抑制剂

p53和MDM2蛋白相互作用抑制剂手性是p53和MDM2蛋白之间相互作用的抑制剂。了解更多

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YH239-EE

Catalog No. A14118
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Mdm2 抑制剂

YH239-EE是有效的p53-MDM2拮抗剂和凋亡诱导剂。了解更多

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MI-773

Catalog No. A15440
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MDM2 抑制剂

MI-773是可用的MDM2拮抗剂，Ki为0.88 nM。了解更多

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WK23

Catalog No. A14051
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MDM2/MDMX 抑制剂

WK23是基于四个芳香族基团的抑制剂，能够有效填充MDM2/MDMX的结合口袋，其对MDM2/MDMX的中位抑制浓度（IC50）值分别为1.17和36 uM。了解更多

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NVP-CGM097

Catalog No. A16326
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MDM2 抑制剂

NVP-CGM097是一种有效的选择性MDM2抑制剂。具有潜在抗肿瘤活性的口服生物利用型HDM2拮抗剂。了解更多

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RG7112

Catalog No. A11523
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selective p53-MDM2 抑制剂

RG7112是首个临床小分子MDM2抑制剂，HTRF IC50为18 nM，设计用于占据MDM2的p53结合口袋。了解更多

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MX-69

Catalog No. A16348
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MDM2/XIAP 抑制剂

MX-69是MDM2/XIAP抑制剂，用于癌症治疗。了解更多

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MI-773 (SAR405838)

Catalog No. A14423
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Mdm2 抑制剂

MI-773 (SAR405838)是一种新的MDM2-p53相互作用的小分子抑制剂，以高亲和力（Ki = 0.88 nM）结合MDM2，并阻断p53-MDM2相互作用。了解更多

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MDM2 Inhibitor

Catalog No. A13582
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MDM2 抑制剂

MDM2 Inhibitor是一种细胞可渗透的硼烷基查尔酮，表现出与MDM2的强结合，并不可逆地破坏MDM2/p53蛋白复合物。了解更多

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