Sirtuins

Inhibitory Selectivity

Catalog No.	Inhibitor Name	SIRT1	SIRT2	SIRT3	Sirtuin	Other
A10377	Selisistat (EX 527)	****
A12226	Sirtinol	*	**
A15902	SirReal2		****
A14221	Splitomicin				**
A14225	AGK2		***
A12305	Tenovin-6	***		*		p53

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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Sirtinol

Catalog No. A12226
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sirtuin 抑制剂

Sirtinol是Sirtinol NAD依赖组蛋白去乙酰化酶的细胞渗透性特异性抑制剂。在无细胞分析中，它是一种特异性SIRT1和SIRT2抑制剂，IC50分别为131 μM和38 μM。了解更多

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Inauhzin

Catalog No. A12527
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SIRT1 抑制剂

Inauhzin是一种有效的SirT1/IMPDH2 的双重抑制剂，可通过抑制SIRT1活性有效地重新激活p53，促进人类癌细胞的p53依赖性凋亡，而不会引起明显的遗传毒性应激。了解更多

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EX 527 (Selisistat)

Catalog No. A10377
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SIRT1 抑制剂

EX 527 (Selisistat)是一种有效的选择性SIRT1 III类组蛋白脱乙酰基酶抑制剂，在无细胞分析中的IC50为38 nM。了解更多

Product Citations (5)

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- Takeshi Nakamura, .et al. Effects of NAD+ Synthesis Levels on Sirtuin 1 Deacetylase Activity in Mammalian Cells, Shimane Journal of Medical Science, 2022, 38 (2), 59-66
- Bugga Paramesha, .et al. Sirt1 and Sirt3 Activation Improved Cardiac Function of Diabetic Rats via Modulation of Mitochondrial Function, Antioxidants (Basel), 2021, Feb 24;10(3):338 PMID: 33668369
- Wenhui Yao, .et al. Icariin ameliorates endothelial dysfunction in type 1 diabetic rats by suppressing ER stress via the PPARα/Sirt1/AMPKα pathway, J Cell Physiol, 2020, 07 August
- Guang Bai, .et al. Chapter 1 - Epigenetic Tools in Chronic Pain Studies, Epigenetics of Chronic Pain, 2019, Pages 1-48
- Yoshikawa A, .et al. Deletion of Atf6α impairs astroglial activation and enhances neuronal death following brain ischemia in mice, J Neurochem, 2015, Feb;132(3):342-53 PMID: 25351847