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| Catalog No. | Inhibitor Name | STAT1 | STAT3 | STAT5 | Other |
|---|---|---|---|---|---|
| A10817 | S3I-201 | * | |||
| A12733 | Stattic | ** | |||
| A14249 | SH-4-54 | **** | **** | ||
| A10244 | Cryptotanshinone | ** | |||
| A10396 | Fludarabine | ||||
| A16220 | Nifuroxazide | ||||
| A13474 | Napabucasin | ||||
| A15363 | Cucurbitacin I | JAK2 | |||
| A15364 | SD 1008 | JAK2 | |||
| A15366 | ZM 449829 | JAK3, EGFR, JAK1, CDK4 | |||
| A15729 | Corylifol A | * | |||
| A15885 | HO-3867 | ||||
| A10087 | Artesunate | EXP1(a membrane glutathione S-transferase) |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
24 个项目
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STAT3-IN-1
Catalog No. A12232 STAT3 inhibitorSTAT3-IN-1 (compound 7d) is an excellent, selective and orally active STAT3 inhibitor, with IC50 values of 1.82 μM and 2.14 μM in HT29 and MDA-MB 231 cells, respectively. STAT3-IN-1 (compound 7d) induces tumor apoptosis. 了解更多 -
STAT3-IN-3
Catalog No. A18479 STAT3 inhibitorSTAT3-IN-3 is a potent and selective inhibitor of signal transducer and activator of transcription 3 (STAT3). 了解更多 -
Napabucasin
Catalog No. A13474 -
Homoharringtonine
Catalog No. A14490 Stat3 抑制剂 & Apoptosis inducer同型harringtonine是一种头孢他辛生物碱，可抑制肝核糖体中二苯丙氨酸和乙酰苯丙氨酰嘌呤霉素的形成。 了解更多 -
STAT5 Inhibitor
Catalog No. A13628 STAT 抑制剂STAT5抑制剂是一种细胞可渗透的非肽烟酰yl，可通过靶向其SH2结构域（针对STAT5βSH2结构域EPO肽结合活性的IC50 = 47μM）来抑制STAT5。 了解更多 -
SH-4-54
Catalog No. A14249 -
Fludarabine (Fludara)
Catalog No. A10396 STAT 抑制剂Fludarabine或fludarabine(fludara)是一种用于治疗血液恶性肿瘤(血细胞癌，如白血病和淋巴瘤)的化疗药物。Fludarabine通过干扰核糖核苷酸还原酶和DNA聚合酶来抑制DNA合成。它对分裂细胞和静止细胞都有活性。 了解更多 -
Fludarabine Phosphate (Fludara)
Catalog No. A10395 Fludarabine Phosphate (Fludara)是一种用于治疗血液恶性肿瘤(血细胞癌，如白血病和淋巴瘤)的化疗药物。氟达拉滨通过干扰核糖核苷酸还原酶和dna聚合酶来抑制DNA合成。它对分裂细胞和静止细胞都有活性。 了解更多 -
Cryptotanshinone
Catalog No. A10244 Stat3 抑制剂Cryptotanshinone是一种STAT3抑制剂，在DU145细胞中能显着阻断STAT3 Tyr705磷酸化，但不能阻断STAT3 Ser727磷酸化，并显着抑制JAK2磷酸化，IC50为?5μM，而不影响上游激酶c的磷酸化。 了解更多 -
Artesunate
Catalog No. A10087 cytochrome oxidase 抑制剂Artesunate是用于治疗疟疾的青蒿素的半合成衍生物。它也被证明可以有效对抗其他寄生虫，例如肝吸虫。青蒿琥酯还显示出针对不同肿瘤类型的癌细胞系的细胞毒性作用。青蒿琥酯已显示出通过抑制类风湿关节炎成纤维细胞样滑膜细胞中的NF-B和PI3激酶/ Akt信号通路来抑制TNF诱导的促炎细胞因子的产生。 了解更多 -
S3I-201 (NSC 74859)
Catalog No. A10817 Stat3 抑制剂S3I-201(NSC 74859)是Stat3的新型抑制剂，可在体外抑制Stat3，Stat3复合物的形成以及Stat3-DNA结合活性（IC50 = 86±33 ?M）和Stat3依赖性转录活性。 了解更多 -
Nitidine chloride
Catalog No. A14701 -
Cucurbitacin I
Catalog No. A15363 JAK2/STAT3 抑制剂Cucurbitacin I（Cucumis sativus L.）可以抑制v-Src转化的NIH 3T3细胞中的磷酸酪氨酸Stat3（信号转导和转录激活因子3）水平。 了解更多 -
ZM 449829
Catalog No. A15366 -
Corylifol A
Catalog No. A15729 -
Nifuroxazide
Catalog No. A16220
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