TAM Receptor

Inhibitory Selectivity

Catalog No.	Inhibitor Name	Mer	Axl	Tyro3	Other
A10996	Cabozantinib		***
A10153	BMS-777607	**	****	****	VEGFR2/KDR,c-Met,Kit
A13741	R428		**		RON,Met,FLT3
A14143	UNC2250	****		*	VEGFR2/KDR,c-Met,Kit
A15904	UNC2025	****	**	**
A15776	TP-0903		**		FLT3
A15917	NPS-1034		***
A13003	LDC1267	***	*	***	Met
A14276	UNC2881	****	*	*

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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UNC 2250

Catalog No. A14143
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Selective Mer Kinase 抑制剂

UNC2250是一种有效的选择性Mer激酶抑制剂。了解更多

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UNC2881

Catalog No. A14276
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Mer tyrosine kinase 抑制剂

UNC2881是特异的Mer酪氨酸激酶抑制剂。了解更多

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UNC569

Catalog No. A13805
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Mer 抑制剂

UNC569是一种新颖的小分子MER抑制剂，在体内和体外均可有效对抗急性淋巴细胞白血病。UNC569是第一种小分子Mer抑制剂。UNC569通过ERK1/2和AKT抑制Mer激活和下游信号传导。了解更多

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LDC1267

Catalog No. A13003
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TAM Receptor 抑制剂

LDC1267是一种高选择性TAM（Tyro3，Axl和Mer）激酶抑制剂，对于Tyro3，Axl和Mer的IC50分别小于5 nM/8 nM/29 nM。了解更多

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NPS-1034

Catalog No. A15917
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c-Met 抑制剂

NPS-1034是双重Met/Axl抑制剂，IC50分别为48 nM和10.3 nM。了解更多

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R916562

Catalog No. A19374
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Axl/VEGFR2 抑制剂

R916562 is an orally active and selective Axl/VEGF-R2 inhibitor with IC50s of 136 nM and 24 nM, respectively. R916562 has anti-angiogenesis and anti-metastasis. 了解更多

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Gilteritinib hemifumarate

Catalog No. A18235
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FLT3/AXL inhibitor

Gilteritinib hemifumarate is a potent FLT3/AXL inhibitor with IC50 of 0.29 nM/0.73 nM, respectively. 了解更多

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S49076

Catalog No. A21407
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MET, AXL/MER, and FGFR1/2/3 inhibitor

S49076 is a novel, potent inhibitor of MET, AXL/MER, and FGFR1/2/3 with IC50 values below 20 nM. 了解更多

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BMS 777607

Catalog No. A21638
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c-Met/Axl/Ron/Tyro3 inhibitor

BMS 777607 is a Met-related inhibitor for c-Met, Axl, Ron and Tyro3 with IC50s of 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM, respectively. 了解更多

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XL184 free base (Cabozantinib)

Catalog No. A10996
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VEGFR 抑制剂

XL184 free base (Cabozantinib)是设计用来抑制多种受体酪氨酸激酶（特别是MET和VEGFR2）的小分子。了解更多

Product Citations (1)

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- Fujita KI, .et al. Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites, J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358
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BMS-777607

Catalog No. A10153
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c-Met 抑制剂

BMS-777607是一种MET酪氨酸激酶抑制剂，与c-Met蛋白或HGFR结合，可防止HGF结合并破坏MET信号通路。了解更多

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R428

Catalog No. A13741
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Axl 抑制剂

R428是Axl激酶的选择性小分子抑制剂，在转移性乳腺癌模型中显示出阻断肿瘤扩散和延长生存期的活性。了解更多

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Gilteritinib (ASP2215)

Catalog No. A14411
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FLT3/Axl 抑制剂

Gilteritinib (ASP2215)是一种有效的FLT3/AXL抑制剂，对具有AML突变或FLT3-ITD和FLT3-D835的AML具有有效的抗白血病活性。了解更多

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- Mohammad Azhar, .et al. Rational polypharmacological targeting of FLT3, JAK2, ABL, and ERK1 suppresses the adaptive resistance to FLT3 inhibitors in AML, Blood Adv, 2022, Aug 31 PMID: 36044389
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TP-0903

Catalog No. A15776
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AXL 抑制剂

TP-0903是一种有效的选择性Axl激酶抑制剂，IC50为27 nM。了解更多

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SGI-7079

Catalog No. A15864
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Axl 抑制剂

SGI-7079是一种新型的选择性Axl抑制剂，以剂量依赖的方式抑制肿瘤的生长，并且是克服EGFR抑制剂耐药性的潜在治疗靶标。了解更多

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Glesatinib hydrochloride

Catalog No. A16257
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MET/Axl 抑制剂

Glesatinib hydrochloride是MET和Axl受体酪氨酸激酶途径的抑制剂，当改变时，它们会驱动肿瘤的生长。了解更多

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